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Research Journal of Pharmacognosy، جلد ۱۲، شماره ۳، صفحات ۳۹-۴۸
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عنوان انگلیسی Physical Dependence and Inhalation Toxicity in Rats Exposed to Smoke of Mimosa pudica L.
چکیده انگلیسی مقاله Background and Objectives: Mimosa pudica L., belonging to the Fabaceae family, has been used in the Cuban traditional culture by exposure to smoke of aerial parts combustion and in the smokable form of cigarettes, for recreational or leisure purposes and medical applications. The aim of this study was to evaluate the toxicity and physical dependence of M. pudica by the acute inhalation toxicity study and spontaneous withdrawal test in rats exposed to smoke inhalation of the plant. Methods: Mimosine content was determined by a colorimetric method. The acute inhalation toxicity study was performed following the Organization for Economic Cooperation and Development test guidelines 433. The addictive potential of the combustion products of the dried aerial parts, was evaluated through a non-precipitated withdrawal test in female Sprague Dawley rats, in both studies using plant doses of 1000 mg/kg. Results: Quantitative analysis of mimosine content in smoke showed levels of 0.62±0.05 µg/mg dried weight. The inhalation toxicity assessment revealed congestion in nasal cavity, focal gliosis in brain and peribronchial pneumonitis. The plant caused signs of physical dependence characterized by the manifestation of hyperactivity (excitability and aggressiveness), piloerection and soft feces, along with decreased body weight and increased rectal temperature during the period of abstinence. Conclusion: Rats exposed to M. pudica showed signs of acute inhalation toxicity similar to smokable substances such as tobacco and marijuana, and evidenced physical dependence comparable to chlordiazepoxide. These findings highlight the potential risks associated with the traditional use of M. pudica in smokable form.
کلیدواژه‌های انگلیسی مقاله Mimosa pudica,mimosine,smoke inhalation injuries,withdrawal symptoms
نویسندگان مقاله Onel Fong Lores |
Center of Toxicology and Biomedicine (TOXIMED), Medical University of Santiago de Cuba, Santiago de Cuba, Cuba.

Clara Azalea Berenguer Rivas |
Faculty of Natural and Exact Sciences, Universidad de Oriente, Santiago de Cuba, Cuba.

Jorge Eduardo De La Vega Acosta |
Center of Toxicology and Biomedicine (TOXIMED), Medical University of Santiago de Cuba, Santiago de Cuba, Cuba.

Juan Esmérido Betancourt Hernández |
Instituto Superior Politécnico Rei Luhuna Ya Nambonga- Ondjiva, Cunene, Angola.

Frankoe Alvarez Limonta |
Faculty of Natural and Exact Sciences, Universidad de Oriente, Santiago de Cuba, Cuba.

Yoandra Mora Tassé |
Center of Toxicology and Biomedicine (TOXIMED), Medical University of Santiago de Cuba, Santiago de Cuba, Cuba.

Miriam Magale Santiago Ortiz |
Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Huixquilucan, México.

Humberto Joaquín Morris Quevedo |
Center of Studies for Industrial Biotechnology (CEBI), Universidad de Oriente, Santiago de Cuba, Cuba.

Marcos Meneses Mayo |
Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Huixquilucan, México.

نشانی اینترنتی https://www.rjpharmacognosy.ir/article_220534_ac0daddfe7c00e2241973dbb6845942f.pdf
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