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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۲۴، شماره ۹۴، صفحات ۱-۱۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Topical formulation of a skin-natural wound healing remedy based on Traditional Persian Medicine
چکیده انگلیسی مقاله
Background: Historical documents highlight various multifocal products for wound management, including the Zaroor Arbaee formulation, which comprises Commiphora myrrha, Boswellia sp., Astragalus fasciculifolius, and Dracaena sp. Objective: This study investigates a novel topical formulation for skin wound healing based on Traditional Persian Medicine, emphasizing these botanicals. Methods: A methanol extract was prepared, and an MTT assay was used to assess cytotoxicity on normal liver cells. Antimicrobial activity was evaluated using the microdilution method according to CLSI guidelines. A 5% topical cream was formulated, and total phenolic, flavonoid, and tannin contents were measured via spectrophotometry. High-performance thin-layer chromatography (HPTLC) was employed for phytochemical profiling, and essential oil extraction was performed to identify volatile constituents. Organoleptic and physicochemical tests were also conducted on the cream. Results: The MTT assay showed no cytotoxicity, and antimicrobial tests confirmed significant antifungal activity. Total phenolic, flavonoid, and tannin contents were 7.59 ± 0.31 mg, 0.54 ± 0.007 mg, and 2.07 ± 0.13 mg per 1.5 g of extract in a 30 g cream, respectively. Essential oil analysis identified furanoeudesma-1,3-diene (32.84%) and curzerene (14.94%) as major constituents. Additional assessments confirmed the cream’s stability and spreadability. Conclusion: Zaroor Arbaee appears to be a promising traditional remedy for skin wound healing.
کلیدواژه‌های انگلیسی مقاله Wound healing, Commiphora myrrha, Boswellia, Astragalus fasciculifolius, Dracaena
نویسندگان مقاله | Maryam Falahatzadeh
Medicinal Plants Processing Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran


| Zahra Sobhani
Department of Quality Control, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran


| Kamiar Zomorodian
Basic Sciences in Infectious Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Seyedeh Sara Hashemi
Department of Histology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


| Mohammad M. Zarshenas
Medicinal Plants Processing Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-2501-5&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فارماکوگنوزی و فارماسیوتیکس
نوع مقاله منتشر شده پژوهشی
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