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Journal of Dental Materials and Techniques، جلد ۱۴، شماره ۲، صفحات ۸۸-۹۴
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عنوان انگلیسی Low-level laser therapy for the regeneration of mandibular bone defects in rabbits
چکیده انگلیسی مقاله Objective: This study aimed to assess the effect of low-level laser therapy (LLLT) on the regeneration of mandibular bone defects in rabbits.Methods: This animal study was conducted on 14 male albino rabbits. Two circular defects 5 mm in diameter were created bilaterally at the angles of the mandible. One side was randomly selected to undergo laser therapy at a wavelength of 905 nm and a power of 20 mW for 2 minutes daily, starting immediately after surgery. The other side served as the sham-irradiated control. Half of the rabbits were sacrificed on day 8, and the other half on day 15. The mandibles of sacrificed animals were resected and subjected to histopathological analysis to measure the percentage of mineralized bone, osteoid matrix and fibrous tissue as well as the number of blood vessels (as the indicator of angiogenesis), fibroblasts, and inflammatory cells. Data were analyzed by paired t-test and independent samples t-test at the significance level of P<0.05.Results: No statistically significant differences were observed between the laser-treated and control sides in any of the measured histopathological parameters at either the 8-day or 15-day time points (P>0.05). On the laser side, a significant increase was observed in the mean percentage of mineralized bone (P=0.022) and osteoid matrix (P=0.002) from day 8 to day 15. The control side revealed no significant changes in the evaluated parameters over time (P>0.05).Conclusions: Low-level laser irradiation may accelerate the regeneration of mandibular bone defects in rabbits.
کلیدواژه‌های انگلیسی مقاله Biostimulation, bone defect, bone regeneration, Laser therapy, Low-level laser, Osteogenesis
نویسندگان مقاله | Ali Peimani
Department of Maxillofacial Surgery, Faculty of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.


| Maryam Irannezhad
Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


| Salim Kiani
Faculty of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.


| Moein Arman
Department of Veterinary Medicine, Garmsar Islamic Azad University, Semnan, Iran.


| Morteza Khademalhosseini
Department of Clinical and Surgical Pathology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
نشانی اینترنتی https://jdmt.mums.ac.ir/article_26209.html
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نوع مقاله منتشر شده Original Article
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