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Nanomedicine Journal، جلد ۱۲، شماره ۳، صفحات ۴۳۳-۴۴۲
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عنوان انگلیسی Silver-hollow mesoporous silica nanoparticles for clarithromycin delivery in an animal model of helicobacter pylori
چکیده انگلیسی مقاله Background: Nanoparticle-based drug delivery systems offer a promising approach to overcoming antimicrobial resistance and enhancing therapeutic efficacy.Objective(s): This study aimed to evaluate the efficacy of silver-hollow mesoporous silica nanoparticles (Ag-HMSNs) in the targeted delivery of clarithromycin for eradicating Helicobacter pylori (H. pylori).Materials and Methods: A synergistic formulation comprising silver nanoparticles and clarithromycin-loaded hollow mesoporous silica nanoparticles (Ag-HMSNs@CLT) was examined for its antibacterial activity against H. pylori.  The effectiveness of various anti-H. pylori formulations was determined using in vitro inhibition assays and in vivo bacterial load reduction studies.Results: The hollow mesoporous silica nanoparticles (HMSNs) demonstrated a high drug-loading capacity, with a clarithromycin content of 27%. The minimum inhibitory concentrations (MIC) for silver nanoparticles (Ag NPs), clarithromycin (CLT), and Ag-HMSNs@CLT were <2 μg/mL, <0.5 μg/mL, and <0.25 μg/mL, respectively. Among the tested formulations, Ag-HMSNs@CLT exhibited the most pronounced reduction in bacterial load during in vivo studies and significantly mitigated inflammation, as evidenced by hematoxylin-eosin staining.Conclusion: The developed nanoparticle-based drug delivery system exhibited excellent drug-loading efficiency and controlled drug release over an extended period. This study highlighted the potential synergistic effects of combining anti-H. pylori agents and their efficacy in reducing bacterial growth and alleviating gastrointestinal complications associated with H. pylori infection.
کلیدواژه‌های انگلیسی مقاله Drug liberation, Drug delivery systems, Helicobacter pylori, Mesoporous silica nanoparticles
نویسندگان مقاله | Soroush Mirfakhraee
Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Reza Mirnejad
Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran


| Maryam Iman
Department of Pharmaceutics, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_26056.html
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