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Nanomedicine Journal، جلد ۱۲، شماره ۳، صفحات ۵۲۹-۵۴۵
عنوان فارسی
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عنوان انگلیسی Bioimaging comparison between synthesized carbon quantum dots and nanodiamonds
چکیده انگلیسی مقاله Objective(s): Scientists have been focused on finding access to the potential of different materials, incredibly natural substances. This work compared two categories of nanoscale materials based on carbon sources, including carbon quantum dots (C-QDs) and detonation nanodiamonds (DNDs). Materials and Methods: The hydrothermally synthesized C-QDs from Salvia Hispanic L. and DNDs were compared through physicochemical tests such as ultra-violet spectrophotometry (UV-Vis), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and field emission scanning microscopy (FESEM). Then, we investigated their cytotoxicity and biocompatibility on HEK293 and HepG2 cell lines, respectively. To focus on nanoparticle biodistribution and shelf life throughout the in vivo studies of rats, C-QDs and DNDs were labeled by Technetium (99mTc) radioisotope for tracking purposes. Results: The characterization and cytotoxicity outcomes of C-QDs and DNDs confirmed both cases' relative intrinsic similarity and non-toxicity, which also gained permission to enter the in vivo studies of rats.Conclusion: According to biodistribution assessments, despite the slight differences between their biological properties, C-QDs, and DNDs exhibited different bioaccumulation tendencies toward organ selection.
کلیدواژه‌های انگلیسی مقاله Carbon quantum dots, Technetium, Nanodiamonds, Hydrothermal synthesis, Bioimaging
نویسندگان مقاله | Somayeh Marouzi
Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran


| Shirin Sammak
Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Kayvan Sadri
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Majid Darroudi
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://nmj.mums.ac.ir/article_25565.html
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