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Middle East Journal of Cancer، جلد ۱۶، شماره ۳، صفحات ۲۳۸-۲۴۸
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عنوان انگلیسی Prevalence and Clinicopathologic Features of HER2 Overexpression in Endocervical Adenocarcinoma
چکیده انگلیسی مقاله Background: Endocervical adenocarcinoma (ENCA) has poor prognosis and is increasing in developing countries. Human epidermal growth factor receptor 2 (HER2) overexpression in ENCA is not fully known. The aim of this study was to assess the prevalence and clinicopathological features of HER2 overexpression in ENCA.
Method: In this cohort study, 48 ENCA cases were reclassified using the World Health Organization (WHO) classification. Whole-tissue sections were stained for HER2 by immunohistochemistry (IHC) and scored using 2017 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) protocol (negative= 0, 1+, equivocal= 2+, and positive= 3+). Fluorescent in situ hybridization (FISH) assay was performed for 2+ stained cases. Invasion growth pattern and clinicopathologic features were investigated. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS) and Statistical software for data science (STATA) with chi square, Fischer exact, independent sample t-test, and one-way Analysis of Variance (ANOVA) at 0.05 significance level.
Results: 16.6% of ENCAs overexpressed HER2, IHC3+ (n=6) and IHC2+ (n=2). No human papilloma virus (HPV)-independent case was found. HER2 was expressed in half of the invasive stratified mucin-producing carcinomas (ISMICs) (P < 0.05) and was not associated with stage, metastasis, lymph-vascular space invasion, lymph node metastasis, or pattern of invasion (P > 0.05). 
Conclusion: ENCAs, including HPV-associated subtypes, overexpress HER2 in about 16.6% of the cases. Overexpression in ISMIC is significantly higher than the other subtypes, which can be considered for therapeutic trials in this histopathologic subcategory.
کلیدواژه‌های انگلیسی مقاله Uterine cervical neoplasms,HER2 protein,Immunohistochemistry,Prognosis
نویسندگان مقاله Niusha Momeni |
Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Fatemeh Nili |
Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Fereshteh Ameli |
Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Soheila Sarmadi |
Department of Pathology, Yas Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Elham Mirzaian |
Department of Pathology, Dr Shariati Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Farnaz Moravej-Salehi |
Department of Pathology, Yas Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Narges Zamani |
Department of Gynecology Oncology, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_50530_0da249673a43159d98b69cd973ead445.pdf
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