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Middle East Journal of Cancer، جلد ۱۶، شماره ۳، صفحات ۲۸۸-۲۹۶
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عنوان انگلیسی The Safety and Efficacy of Cold Atmospheric Plasma as a Novel Therapy: An in vivo Study
چکیده انگلیسی مقاله Background: Cold atmospheric plasma (CAP) may reduce bacteria and aid wound healing through reactive oxygen species. Recent trials support CAP for chronic wounds, but its effectiveness is not well-proven. This studyevaluates the efficacy of CAP on wound healing rate.
Method: This cross-sectional study was conducted sequentialy to investigate the impact of CAP intervention on wound healing in rats over a period from 2022 to 2023. The study was carried out at the Atomic Energy Organization of Iran.A total number of 16 ratswere divided into three groups based on the duration of CAP exposure: Group 1 (0 minutes), Group 2 (3 minutes), and Group 3 (5 minutes). Continuous variables were reported as mean ± SD. Group differences were analyzed using ANOVA or Kruskal-Wallis. A P-value <0.05 was considered statistically significant.
Results: Day zero analysis revealed an absence of acute inflammatory response, with neutrophils consistently absent across all groups. Lymphocytes were predominantly absent, with a mild presence observed in most cases. Granulation tissue was mainly absent, and when present, it exhibited minimal extent. Blood vessel count was mostly below 20 per 10 high-power fields, with a slightly higher count in the 5 minute CAP intervention group. Fibroblasts were mostly absent, and when present, they were found in minimal extent. Ulcers, keloids, and hypertrophic scars were largely absent in all cases. Day seven and fourteen analyses revealed no significant differences between the left and right sides of the wounds for most variables.
Conclusion: CAP therapy showed promise for acute wound healing in rats, with minimal inflammation and scar formation. Further research is needed to optimize its use.
کلیدواژه‌های انگلیسی مقاله cold plasma,Wound healing,CAP therapy,Reactive oxygen and nitrogen species
نویسندگان مقاله Atieh Akbari |
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mahdiyeh Bakhtiyari-Ramezani |
Plasma Physics and Nuclear Fusion Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Dorsa Najari |
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mehdi Aziz Mohamadlooha |
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Afshin Moradi |
Department of Pathology, , Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mahdis Bayat |
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Fereshteh Abbasvandi |
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Batoul Khoundabi |
Iran Helal Institute of Applied-Science and Technology, Red Crescent Society of Iran, Tehran, Iran

Mohammad Esmaeil Akbari |
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://mejc.sums.ac.ir/article_50500_933f3dcd64f20c1b5df6c29965ee9292.pdf
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