این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Pediatric Hematology and Oncology، جلد ۱۵، شماره ۳، صفحات ۵۸۲-۵۸۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Hematopoietic Stem Cell Transplantation and Immune System Suppression in Severe Aplastic Anemia
چکیده انگلیسی مقاله
Aplastic anemia (AA) is characterized by pancytopenia and hypocellular bone marrow and can be either acquired or constitutional. Acquired AA results from autoimmune-mediated destruction of hematopoietic stem cells, often triggered by toxic agents inducing neo or cryptic antigens that activate immune responses. Although rare, acquired AA remains a serious condition typically managed with immunosuppressive therapy and supportive care. Constitutional forms, such as Fanconi anemia (FA) and Dyskeratosis Congenita (DC), are also uncommon and associated with genetic defects in DNA repair or telomere maintenance. Accurate differentiation between acquired and constitutional AA is critical for effective management.
In our center, 15 patients were diagnosed with AA between 2016 and 2021 (acquired = 5, constitutional = 10). Patients with acquired AA received immunosuppressive therapy. Those with constitutional AA and HLA-matched donors underwent bone marrow transplantation following a conditioning regimen of busulfan, cyclophosphamide, and rabbit ATG. Cyclosporine was initiated two days prior to transplantation and continued for 6–12 months or longer. Despite the high mortality risk associated with untreated AA, all patients achieved favorable outcomes with no mortality, underscoring the critical role of early diagnosis and individualized treatment in improving survival in AA.
کلیدواژه‌های انگلیسی مقاله Aplastic Anemia, Bone Marrow Transplantation, Bone Marrow Failure Disorders, Dyskeratosis Congenital, Fanconi Anemia
نویسندگان مقاله | Hassan Mahmoodi-Nesheli
Associate Professor, Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran


| Ahmad Tamaddoni
Professor, Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran


| Somayeh Shirkosh
PhD Candidate in Nursing, Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran


| Mohtaram Hashemikarooyee
BSc of Nursing, Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran


| Khadije Jafarzadeh
BSc of Nursing, Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, IR Iran
نشانی اینترنتی http://ijpho.ssu.ac.ir/browse.php?a_code=A-10-134-2&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده هماتولوژی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات