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Iranian Journal of Public Health، جلد ۵۴، شماره ۷، صفحات ۱۳۹۹-۱۴۱۰
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عنوان انگلیسی Regenerative Medicine in the Treatment of Alzheimer's Disease: A Narrative Review
چکیده انگلیسی مقاله Alzheimer’s disease (AD) is one of the progressive neurodegenerative diseases, memory impairments and multiple cognitive and behavioral deficits characterize that. We aimed to evaluate the molecular mechanisms involved in the pathogenesis of AD. It introduces the regenerative medicine approach as a novel therapeutic strategy based on the pathogenesis of AD that would be efficient. Our data was collected using databases such as the Web of Science, PubMed, Scopus, and Google Scholar. We summarized the available therapeutic strategies to induce neurodegeneration that can increase the number of neurons and their survival and improve the plasticity of synapses and synaptic activity. There is a different approach to treatment. In first-line treatment, focusing declines the amyloid beta and hypophosphorylated tau protein accumulation. It inhibits acetylcholinesterase, but in regenerative medicine focusing on treatment via gene therapy, cell therapy, and tissue engineering. As a proposed solution for AD in recent years, the use of inhibitors of the pathogenesis of AD is known as a supportive therapeutic approach, but the multi-potential treatment of regenerative medicine has been able to provide promising results in treating neurodegenerative patients.
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نویسندگان مقاله | Mana Shojapour
Molecular and Medicine Research Center, Arak University of Medical Sciences, Arak, Iran


| Samira Asgharzade
1. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran 2. Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/36783
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