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Tanaffos، جلد ۲۳، شماره ۳، صفحات ۲۳۸-۲۴۵
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عنوان انگلیسی Potential Laboratory Markers in COVID-19 Patients with Gastrointestinal Impairments as Prognosticators of the Disease Severity
چکیده انگلیسی مقاله Background: The new coronavirus infectious disease, COVID-19, is constantly killing people around the world. The main clinical symptoms of COVID-19 include fever, cough, shortness of breath, weakness, fatigue, and sputum/discharge. Gastrointestinal (GI) impairments are often associated with respiratory manifestations in COVID-19 patients. The current study aimed to examine potential laboratory markers in COVID-19 patients with gastrointestinal impairments as prognosticators of disease severity. Materials and Methods: In the present study, hospitalized COVID-19 patients with respiratory symptoms as the main clinical manifestations and gastrointestinal symptoms were studied to evaluate relevant blood biomarkers including vitamins B12, D, and K in addition to albumin, pre-albumin, calcium, and magnesium. Results: Sixty individuals (29 males and 31 females) participated in the study aged between 29 and 72 years, with a mean of 45.87 years. Our results showed a significant increase in albumin, pre-albumin, transferrin, and vitamin K and a significant decrease in magnesium and vitamin B12. Decreases in calcium and vitamin D were modestly associated with the clinical picture of the patient group. Conclusion: Our findings suggest that monitoring laboratory markers such as transferrin, serum albumin, vitamin K, and magnesium-to-calcium ratio could be valuable prognosticators for COVID-19 infection. They could assist in better patient management and disease control.
کلیدواژه‌های انگلیسی مقاله SARS-CoV-2,COVID-19,Respiratory symptom,biomarker
نویسندگان مقاله Nayebali Ahmadi |
Proteomics Research Center, Department of Medical Lab Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Maryam Shahali |
Department of Viral Vaccines, Production and Complex Research, Pasteur Institute of Iran, Tehran, Iran

Ashkan Alamdary |
Department of Viral Vaccines, Production and Complex Research, Pasteur Institute of Iran, Tehran, Iran

Alireaza Gholami |
Department of Viral Vaccines, Production and Complex Research, Pasteur Institute of Iran, Tehran, Iran

Rasul Moukhah |
Department of Quality Assurance, Production and Complex Research, Pasteur Institute of Iran, Tehran, Iran

Mohammadjavad Hossein Tehrani |
Department of Clinical Biochemistry, Hamadan University of Medical Science, Hamadan, Iran

Delaram Doroud |
Department of Production, Research and Production Complex, Pasteur Institute of Iran

Ariana Alavi |
Department of Production, Research and Production Complex, Pasteur Institute of Iran

Rajab Mardani |
Department of Viral Vaccines, Production and Complex Research, Pasteur Institute of Iran, Tehran, Iran

نشانی اینترنتی https://www.tanaffosjournal.ir/article_726112_9a2d44f9c2ed99af700dd27808d5cd98.pdf
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