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Iranian Journal of Pathology، جلد ۲۰، شماره ۳، صفحات ۲۴۵-۲۵۶
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عنوان انگلیسی The Link Between High Sensitivity Troponin T Levels and Outcomes Among Patients with Congestive Heart Failure: A Systematic Review and Meta-Analysis Study
چکیده انگلیسی مقاله Background & Objective: High-sensitivity cardiac troponin T (hs-cTnT) has emerged as a critical biomarker in cardiovascular diseases, particularly in congestive heart failure (CHF). This systematic review and meta-analysis aimed to assess the association between hs-cTnT levels and clinical outcomes in patients with CHF.
Methods: A comprehensive literature search was performed across multiple databases to identify studies evaluating the relationship between hs-cTnT levels and clinical outcomes in CHF. Eligible studies reported hazard ratios (HRs) or odds ratios (ORs) for all-cause mortality, cardiovascular mortality, or cardiovascular hospitalization.
Results: Elevated hs-cTnT levels were significantly associated with adverse outcomes. The pooled HR and OR for all-cause mortality were 1.70 (95% CI, 1.49–1.94) and 6.19 (95% CI, 3.88–9.86), respectively. For cardiovascular mortality, the pooled HR was 1.59 (95% CI, 1.38–1.83) and the pooled OR was 6.87 (95% CI, 3.93–12.01). For cardiovascular hospitalization, the pooled HR was 1.56 (95% CI, 1.42–1.70) and the pooled OR was 4.32 (95% CI, 2.22–8.39).
Conclusion: Elevated hs-cTnT levels are strongly associated with an increased risk of all-cause mortality, cardiovascular mortality, and cardiovascular hospitalization in patients with CHF. These findings highlight the prognostic value of hs-cTnT in the clinical management of heart failure.
کلیدواژه‌های انگلیسی مقاله High-Sensitivity Troponin T,Congestive heart failure,Mortality,hospitalization,Clinical outcomes
نویسندگان مقاله Alireza Abdollahi |
Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Zohreh Nozarian |
Department of Pathology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Samaneh Salarvand |
Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Elham Pourebrahimi |
Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی https://ijp.iranpath.org/article_726160_84a4aac8de8ae63d9d7963b275d16bc0.pdf
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