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Iranian Journal of Biotechnology، جلد ۲۳، شماره ۳، صفحات ۱۵-۲۵
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عنوان انگلیسی Utilizing Circulating MicroRNAs for Personalized Exercise Programs: Insights into Physiological Adaptations and Individual Responses
چکیده انگلیسی مقاله Background: Circulating microRNAs (c-miRNAs) have emerged as important biomarkers for monitoring physiological responses to exercise. These small, non-coding RNA molecules play a key role in gene expression regulation and reflect the body’s adaptive responses to different exercise modalities, including cardiovascular health, muscle growth, and inflammation.

Evidence Acquisition: This narrative review included articles sourced from databases such as PubMed, Google Scholar, ScienceDirect, Web of Science, and Scopus, without time limitations. Studies on c-miRNAs related to exercise were reviewed, and the search strategy involved using keywords such as "microRNA," "exercise," and "biomarkers." The selected studies were reviewed based on their relevance to exercise-related c-miRNAs and their contributions to the field.

Results: The review identifies multiple c-miRNAs that are sensitive to exercise-induced changes, with miR-1, miR-126, miR-21, and miR-146a showing significant correlations with cardiovascular and muscle adaptations. These findings suggest that c-miRNAs may serve as reliable indicators for individualized training programs, highlighting the importance of molecular responses in tailoring exercise regimens to optimize performance and health outcomes.

Conclusions: c-miRNAs offer promising potential for personalized exercise prescriptions. Future studies should aim to elucidate the full regulatory networks and assess the variability of these biomarkers across diverse populations and exercise modalities. Clinicians and sports practitioners can apply this knowledge to refine training strategies, improving athletic performance and health monitoring.
کلیدواژه‌های انگلیسی مقاله MicroRNAs,Gene Expression Regulation,exercise physiology,Biomarkers,Personalized Medicine,Adaptation Physiological
نویسندگان مقاله Chen Li |
Department of Physical Education, Jinling Institute of Technology, Nanjing 211169, China

Su Zhanguo |
Faculty of Physical Education, Huainan Normal University, Huainan 232038, Anhui, China

نشانی اینترنتی https://www.ijbiotech.com/article_224220_b3c56a4ef6dd62a1b45ef6cc16f62f93.pdf
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