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Archives of Breast Cancer، جلد ۱۲، شماره ۳، صفحات ۲۹۴-۳۰۲
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چکیده فارسی مقاله
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عنوان انگلیسی Results of Neoadjuvant Chemotherapy in ER-Positive HER2/neu-Negative Breast Cancer After 2–8 Courses: NAC in ER+ HER/Neu- BC
چکیده انگلیسی مقاله Background: Neoadjuvant chemotherapy (NCT) is an optimal treatment for estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2/neu)-negative breast cancer. We evaluated the results after 2, 4, 6, and 8 courses. Methods: We conducted a retrospective analysis of the effectiveness of 2 to 8 courses of NCT in 121 patients. NCT consisted of doxorubicin, endoxan, and docetaxel. After NCT, all patients received surgery, radiation, and endocrine therapy. Results: In Group 2, treatment showed no effect in 1 case (4%), while partial response was observed in 6 cases (23%) and stabilization in 19 cases (73%). In the 4-course group, there was no treatment effect in 2 cases (6.5%), partial response in 15 cases (48.4%), and stabilization in 13 cases (41.9%). Additionally, 1 case (3.1%) achieved a pathologic complete response (pCR). In the 6-course group, 1 case (3.1%) showed no treatment effect, 18 cases (56.3%) had a partial response, and 8 cases (25%) exhibited stabilization. A pCR was achieved in 5 cases (15.6%). In the final group (8 courses), 1 case (3.1%) had no treatment response, 18 cases (56.3%) demonstrated partial response, and 4 cases (12.5%) showed stabilization, with 9 cases (28.1%) achieving pCR. The 5-year cancer-specific survival rate ranged from 88.1 ± 6.4% to 96.8 ± 3.2%. Conclusion: Two courses of NCT were ineffective. Tumor progression occurred in 3% to 6% of cases, while the Ki-67 index increased by 9.4% to 22.6%. A pCR was achieved in 3.2% to 15.6% of patients after 4 to 6 courses. Intermediate tumor biopsy can identify cases of treatment resistance or high chemosensitivity.
کلیدواژه‌های انگلیسی مقاله breast neoplasm, neoadjuvant chemotherapy, pathologic complete response, Ki-67
نویسندگان مقاله
نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/1089
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کد مقاله (doi) 10.32768/abc.9253819307482
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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