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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۴، شماره ۷، صفحات ۱۹۲۳-۱۹۳۵
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عنوان انگلیسی In Vitro α -Amylase and α -Glucosidase Inhibitory Effects and Anti-Leukemia Activity of Adicardin, Rosiridin, and Candidone Compounds with in Silico Studies
چکیده انگلیسی مقاله Research on the anti-cancer properties of bioactive chemicals derived from plant-based diets has surged in recent years due to the pressing need to find novel anti-leukemic medicines with reduced adverse effects and greater efficacy and selectivity for AML cells. The calculated IC50 values in this study indicate that the candidone molecule is a promising inhibitor of both α-amylase and α-glucosidase (IC50: 7.46 ± 0.73 and 1.40 ± 0.20 µM). On the other hand, Adicardin (IC50: 24.92 ± 3.01 and 20.18 ±1.58 µM), and rosirid in (IC50: 51.97 ± 6.32 and 40.62 ± 3.74 µM) were found to inhibit both enzymes in this experiment, with good IC50 values for α-amylase and α-glucosidase, respectively. Additionally, the anti-leukemia capabilities of these natural compounds were examined; the effects of these compounds on several cell lines were assessed, and documented the results of the effects of these compounds on several cell lines. When we examine the leukemia results one by one, some cell lines like K562, HL-60, THP-1, and MOLT-4 had the best results for rosiridin (5.32 ± 0.52, 6.94±0.46, 9.11±0.60, and 2.47±0.25 µM). The chemical interactions of adicardin, rosiridin, and candidone with alpha-glucosidase and alpha-amylase were evaluated through various methodologies, including molecular docking studies, MM/GBSA calculations, and Molecular Dynamics (MD) simulations. Additionally, the anti-cancer properties of these compounds were tested against various leukemia cell lines, specifically K562, HL-60, THP-1, and MOLT-4.
کلیدواژه‌های انگلیسی مقاله natural compounds,Anticancer,Enzyme inhibition,Molecular Dynamic,MM/GBSA calculations
نویسندگان مقاله Ling Li |
Department of Oncology, Pingxiang Second People’s Hospital, Jiangxi, 337000, P.R. CHINA

Mingyan Zhong |
Department of Oncology, Pingxiang Second People’s Hospital, Jiangxi, 337000, P.R. CHINA

Yu Liu |
Department of Endocrinology, Pingxiang Second People’s Hospital, Jiangxi, 337000, P.R. CHINA

Fenghua Zhao |
Department of Oncology, Pingxiang Second People’s Hospital, Jiangxi, 337000, P.R. CHINA

نشانی اینترنتی https://ijcce.ac.ir/article_725351_1cf8acd98ab6642762cb911d78edf43f.pdf
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