این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Laboratory Journal، جلد ۱۹، شماره ۳، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The evaluation of the effect of periodic resistance training along with vitamin D3 consumption and mesenchymal stem cell transplantation on cortical TNF-β level in streptozotocin-induced diabetic rats
چکیده انگلیسی مقاله Background and objectives: Inflammation plays a major role in the development and progression of diabetes. Vitamin D deficiency and physical inactivity can also increase the risk of developing type 2 diabetes. Combined therapeutic strategies are promising approaches for the treatment and prevention of diabetes. The aim of this study was to investigate effects of resistance training, vitamin D3 supplementation and adipose-derived mesenchymal stem cell (MSC) transplantation on tumor necrosis factor-beta level in the cerebral cortex of diabetic rats.
Methods: Eighty male Wistar rats (weighing 290±19 g) were randomly divided in to 10 groups: healthy control, sham, diabetes, training, vitamin D, MSC, training+vitamin D, MSC+training, MSC+vitamin D and training+MSC+vitamin D. Training groups were subjected to a resistance training program on ladder. MSC groups received 1.5 × 106 MSCs and vitamin D supplementation groups received 1 microgram/kilogram vitamin D3 eight times. Cortical TNF-β level and fasting serum glucose levels were measured.
Results: After 6 weeks, the combination of resistance training with vitamin D3 supplementation and MSC transplantation (P=0.018) as well as the combination of resistance training with MSCs (P=0.024) significantly reduced diabetes-induced elevation of TNF-β level.
Conclusion: Resistance training with appropriate intensity, duration and recovery between exercise sessions, combined with MSC transplantation and vitamin D3 supplementation has profound anti-inflammatory effects on the cerebral cortex tissue of diabetic rats. This type of intervention, especially the transplantation of MSCs, may be a promising protective strategy against some complications of diabetes.
 
کلیدواژه‌های انگلیسی مقاله Resistance training, Vitamin D, Stem cell, Diabetes, Inflammation
نویسندگان مقاله | Seyed Abdollah Hashemvarzi
Department of Exercise Physiology, Sar.C., Islamic Azad University, Sari, Iran


| Behrooz Mohammadnezhad
Department of Exercise Physiology, Sar.C., Islamic Azad University, Sari, Iran
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-404-2&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده ایمنی شناسی
نوع مقاله منتشر شده Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات