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Iranian Journal of Microbiology، جلد ۱۷، شماره ۴، صفحات ۶۲۹-۶۳۵
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عنوان انگلیسی Transplant failure in relation to BK viremia status among kidney transplant recipients in Jordan
چکیده انگلیسی مقاله Background and Objectives: BK polyomavirus (BKPyV) poses a significant threat to kidney transplant (KT) recipients due to immunosuppression, leading to BK-associated nephropathy (BKVN) and reduced transplant survival. This study aimed to determine the prevalence of BKPyV among kidney transplant recipients in Jordan and to evaluate the association between BKPyV activity and kidney transplant outcomes. Materials and Methods: A retrospective observational study was conducted at the Jordanian Royal Medical Services Hospital (JRMS) from 2021 to 2024. Blood samples (n=157) from kidney transplant recipients were collected, and quantitative real-time PCR was performed to detect BKPyV DNA. Results: The prevalence of BKPyV infection among kidney transplant recipients was 40.8% (n=64). Transplant failure occurred in 36% of cases (n=57), with BKPyV-DNA viremia observed in 74% of those with transplant failure (n=42). The prevalence of infection was significantly higher in patients under 18 years of age (81%, p<0.001) and in males (72%, p<0.001). BKPyV infection increased the odds of transplant failure tenfold. Conclusion: In Jordan, the prevalence of BKPyV among kidney transplant recipients is high, particularly in males and younger patients. BKPyV significantly increases the risk of kidney transplant failure. Other studies are needed to further elucidate the impact of BKPyV on kidney transplant rejection and complications.
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نویسندگان مقاله | Rabaa Athamneh
Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan


| Reema Bani Saeed
Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan


| Omaymah Abulannaz
Department of Pharmacology, Jordan University of Science and Technology, Irbid, Jordan


| Rawan Abudalo
Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan


| Muna Oqal
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5323
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