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The Journal of Tehran University Heart Center، جلد ۲۰، شماره ۱، صفحات ۲۱-۲۸
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عنوان انگلیسی Association between Hypertension with and without Left Ventricular Hypertrophy and the Expression of a Panel of microRNAs in an Iranian Population
چکیده انگلیسی مقاله Introduction: Considering the role of micro-RNAs in hypertension (HTN), the present study was conducted to investigate the expression of a selected micro-RNA panel among the hypertensive individuals with and without left ventricular hypertrophy (LVH) compared with the controls in an Iranian population. Methods: A cross-sectional study with case-control sampling was conducted. The study groups were control, hypertension and hypertension plus LVH. Based on literature review, a panel of micro-RNAs including Mir-1, Mir-21, Mir-29a, Mir-29b, Mir-133, Mir-155, Mir-221 and Mir-222 were selected and studied by real-time PCR. General linear model was used for gene expression study. Results: A total of 100 samples were studied. Mir-29a and Mir-133 were used for calculation endogenous control. Mir-29b and Mir-221 did not show any association with the groups of study (P >0.2). Mir-1 showed down-regulation in both case groups (P <0.05); but this down-regulation did not remain significant after adjusting the effects of the potential confounders (P: 0.05 – 0.2). Mir-21 showed down-regulation in HTN+LVH group (P <0.05). Years of hypertension diagnosis was associated with up-regulation of Mir-155 and Mir-222. The strongest association was for Mir-222 that the groups of study could explain 25.7% of its variation (the largest R2 among the models). Conclusion: Hypertension without LVH might be associated with down-regulation of Mir-1 and Mir-155, and up-regulation of Mir-222. Hypertension along with LVH might be associated with down-regulation of Mir-1 and Mir-21, and up-regulation of Mir-222. Increasing years of experiencing hypertension was correlated with up-regulation of Mir-155 and Mir-222. The largest effect size was for Mir-222.
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نویسندگان مقاله | Shokoufeh Hajsadeghi
Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran


| Reza Nekouian
Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical Sciences, Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran


| Maryam Mollababaei
Department of Medical Biotechnology, School of Allied Medicine, Iran University of Medical Sciences,


| Hamed Motevalli
Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


| Ehsan Kalantar
Student Research Committee, Iran University of Medical Sciences, Tehran, Iran


| Aida Iranpour
Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences


| Seyyed Amir Yasin Ahmadi
Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran


| Mohammad Sedigh Dakkali
Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://jthc.tums.ac.ir/index.php/jthc/article/view/1990
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