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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۱۰، صفحات ۱۳۳۵-۱۳۴۳
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عنوان انگلیسی Effects of Nrf-2/HO-1, NF-κB/Cox-2/TLR-4, and Bax/Bcl-2/caspase-3 pathways in alleviating azithromycin-induced cardiotoxicity in rats: Potential cardioprotective role of crocin
چکیده انگلیسی مقاله Objective(s): This study aimed to investigate the potential protective effects of crocin against azithromycin (AZ)-induced cardiotoxicity.Materials and Methods: The experimental design consisted of four groups: Control, crocin, Azithromycin, and crocin plus Azithromycin (AZ+CR 50). To evaluate oxidative stress, inflammation, and apoptosis in cardiac tissue, a combination of biochemical, molecular, and histological techniques was employed. Biomarkers such as superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), nuclear factor erythroid 2–related factor 2 (Nrf-2), and heme oxygenase-1 (HO-1) were assessed to determine anti-oxidant status, while malondialdehyde (MDA) and advanced oxidation protein products (AOPP) were measured as indicators of oxidative damage. Protein levels of inflammatory markers NF-κB and toll-like receptor 4 (TLR-4) and apoptotic regulators Bax, Bcl-2, and Caspase-3 were quantified.Results: Crocin treatment effectively attenuated AZ-induced oxidative stress by enhancing anti-oxidant enzyme activity and reducing MDA and AOPP levels. Furthermore, crocin significantly down-regulated the expression of NF-κB and TLR-4 proteins, indicating reduced inflammation. The proapoptotic proteins Bax and Caspase-3, which were elevated following AZ exposure, were markedly decreased by crocin co-treatment. Conversely, the reduced expression of the antiapoptotic protein Bcl-2 caused by AZ was restored by crocin. In addition, AZ administration led to increased levels of COX-2 and MAPK-3, both of which were down-regulated following crocin treatment. Histological analysis revealed that crocin reduced degenerative and necrotic changes in heart tissue caused by AZ.Conclusion: These findings suggest that crocin exerts cardioprotective effects against AZ-induced damage by modulating oxidative stress, inflammation, and apoptosis.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Azithromycin, Cardiotoxicity, Crocin, Inflammation, Oxidative stress
نویسندگان مقاله | Tuba Dogan
Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey


| Betul Apaydin Yildirim
Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey


| Kubra Asena Terim Kapakin
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey


| Metin Kiliclioglu
Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey


| Omercan Alat
Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey
نشانی اینترنتی https://ijbms.mums.ac.ir/article_26316.html
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