|
|
Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۱۰، صفحات ۱۴۲۸-۱۴۳۷
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژههای فارسی مقاله |
|
|
| عنوان انگلیسی |
Repurposing Artrestan (Sacubitril/Valsartan), unveiling its anti-inflammatory and fibrinolytic properties in ulcerative colitis in rats |
|
| چکیده انگلیسی مقاله |
Objective(s): Ulcerative colitis (UC) is an inflammatory disorder that is managed with various treatments, which have varying degrees of effectiveness and side effects, highlighting the need for new and more effective alternatives. In this study, we applied Artrestan (Sacubitrol/Valsartan), which has potent anti-inflammatory properties, alone or in combination with Mesalazine, in the treatment of UC animal models. Materials and Methods: Thirty male rats were randomly divided into control, colitis, Artrestan (60 mg/kg/day), Mesalazine (100 mg/kg/day), and Artrestan plus Mesalazine groups. UC was induced by intrarectal administration of acetic acid, followed by a 5-day course of oral medication, during which the disease activity index (DAI), including diarrhea, weight loss, and rectal bleeding, was assessed daily. Macroscopic and microscopic examinations, as well as assessments of oxidant-anti-oxidant, pro-inflammatory, and pro-fibrotic factors, were performed on colonic tissue. Results: Administration of Artrestan, especially in combination with Mesalazine, significantly decreased DAI and histological lesion scores in the microscopic assessment. Moreover, Artrestan modulated oxidant-anti-oxidant balance by increasing the activities of superoxide dismutase (SOD) and catalase (CAT) and reducing malondialdehyde (MDA) in colon tissue. Expression of inflammatory markers, including Interleukin 6 (IL-6) and Tumor necrosis factor-alpha (TNF-α), was decreased in the treated groups compared to the untreated group. Artrestan also attenuated fibrosis and collagen deposition in colon tissues, which was accompanied by a reduction in the expression of Transforming growth factor beta (TGF-β).Conclusion: Our findings suggest the therapeutic potential of Artrestan in combination with Mesalazine for the treatment of UC, as it modulates clinical symptoms, improves the oxidant-anti-oxidant balance, and reduces pro-inflammatory and pro-fibrotic factors, supporting further investigations in the clinical phase. |
|
| کلیدواژههای انگلیسی مقاله |
Artrestan (Sacubitril/Valsartan), Fibrosis, Inflammation, Mesalazine, Ulcerative colitis |
|
| نویسندگان مقاله |
| Khatereh Kharazmi
Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran|Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
| Seyedeh Elnaz Nazari
Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Moein Eskandari
Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| fereshteh Asgharzadeh
Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Akram Aminian
Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
| Amir Avan
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Molecular Medicine Group, Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Seyed Mahdi Hassanian
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Majid Khazaei
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
|
|
| نشانی اینترنتی |
https://ijbms.mums.ac.ir/article_26395.html |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|