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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۱۰، صفحات ۱۴۳۸-۱۴۴۶
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عنوان انگلیسی Cardioprotective effects of lycopene-loaded nanoparticles against isoproterenol-induced myocardial injury
چکیده انگلیسی مقاله Objective(s): This study aimed to investigate the cardioprotective effects of lycopene loaded ovalbumin chitosan nanoparticle (L-OCNPs) against isoproterenol (ISO)-induced myocardial injury.Materials and Methods: H9c2 cardiomyoblasts were treated with various concentrations of L-OCNPs (5, 10, 15, 25, and 50 µg/ml) for 24 hr, followed by exposure to ISO (100 µM) for an additional 24 hr. Cell viability, oxidative stress, mitochondrial function, and nuclear damage were assessed using various biochemical and molecular techniques. Molecular docking studies were conducted to explore the binding interactions between L-OCNPs and the Nrf2 protein. Results: L-OCNPs exhibited significant cytoprotective effects against ISO-induced cytotoxicity. They effectively reduced oxidative stress by scavenging reactive oxygen species and up-regulating antioxidant enzymes. L-OCNPs also preserved mitochondrial function by maintaining mitochondrial membrane potential and reducing mitochondrial damage. Furthermore, they protected against nuclear damage by inhibiting DNA fragmentation and apoptosis. Molecular docking studies revealed that L-OCNPs, particularly (all-E)-Lycopene and 5Z-Lycopene, interact with the Nrf2 protein, suggesting a potential mechanism of action. Histopathological analysis of rat hearts confirmed the cardioprotective effects of L-OCNPs against ISO-induced myocardial injury. Conclusion: L-OCNPs demonstrate promising cardioprotective properties by mitigating oxidative stress, preserving mitochondrial function, and preventing nuclear damage. These outcomes propose that L-OCNPs may be a potential therapeutic agent for the prevention and treatment of cardiovascular diseases.
کلیدواژه‌های انگلیسی مقاله Cardiomyoblast, cardioprotective, Chitosan, Lycopene, Myocardial injury
نویسندگان مقاله | Xia Liu
Department of Intensive Care Medicine, The Third People’s Hospital of Chengdu. Chengdu, Sichuan, 610031, China


| Ya Liu
Department of Cardiovascular Medicine, Ezhou Central Hospital, Ezhou, Hubei, 436000, China


| Chunwei Yu
Operating Room, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250000, China


| Guang Xu
Department of Cardiovascular Medicine, Ezhou Central Hospital, Ezhou, Hubei, 436000, China


| Xiuyuan Feng
Department of Cardiovascular Medicine, Ezhou Central Hospital, Ezhou, Hubei, 436000, China


| Jia Tang
Department of Liver and Gallbladder Surgery, Jiangjin District Central Hospital of Chongqing, Chongqing, 402260, China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_26414.html
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