این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۵، صفحات ۱۵۱۹-۱۵۳۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Protective effects of Elaeagnus angustifolia L. fruit extract on CCl4-induced oxidative stress and inflammation in rats liver
چکیده انگلیسی مقاله Objective: Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess Elaeagnus angustifolia L. fruit extract's potential in shielding rat livers from CCl4 damage.Materials and Methods: 30 Male Wistar rats were randomly divided into five groups: normal control (received distilled water), E. angustifolia hydroalcoholic extract control, CCl4 control, E. angustifolia extract pretreatment (600 mg/kg), and silymarin pretreatment (100 mg/kg). After 14 days of oral administration of extracts, CCl4 was injected intraperitoneally. The samples were collected 48 hr later. Histological and biochemical analyses were then carried out.Results: CCl4 injection caused significant (p<0.001) changes in liver serum enzymes, lipid profile, bilirubin, total protein, serum albumin, antioxidant enzymes, malondialdehyde, Inflammatory cytokines, and liver tissue morphology. E. angustifolia extract pre-treatment significantly (p<0.05) returned changes to the normal state.Conclusion: This study's findings revealed that E. angustifolia extract pretreatment could reduce liver injury caused by CCl4 in rats.
کلیدواژه‌های انگلیسی مقاله Elaeagnus angustifolia L, Carbon tetrachloride, Liver damage, Oxidative stress, Antioxidant
نویسندگان مقاله | masoud ojarudi
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Ali Golchin
Department of Applied Cell Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran


| Hamid Reza Karamdel
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Mohammad Valilo
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran


| Parviz Ranjbarvan
Department of Applied Cell Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_25915.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات