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Journal of Medical Microbiology and Infectious Diseases، جلد ۱۳، شماره ۲، صفحات ۱۱۱-۱۱۷
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عنوان انگلیسی Clinical Characteristics, Breakthrough Infections, and Reinfections with SARS-CoV-2 among Healthcare Workers in the Omicron Wave
چکیده انگلیسی مقاله Introduction: A global increase in infections was noted with the emergence of the Omicron variant, which exhibited immune evasion capabilities against previous infections or vaccinations. Healthcare workers (HCWs) faced increased risk from occupational exposure. This study aimed to investigate the clinical characteristics, reinfection rates, and breakthrough infections among HCWs during the Omicron wave. Methods:  A total of 312 HCWs who tested positive for SARS-CoV-2 during the Omicron wave (January 1–February 22, 2022) were enrolled in the study after providing consent. Participating HCWs completed a questionnaire to provide details on demographics, symptoms at testing, comorbidities, vaccination status, and prior COVID-19 infection history. Clinical outcomes were also recorded. Cases of reinfection and breakthrough infection were identified. Results: The median age of HCWs in the study was 32.9 years. The frequency of infection was higher in females (56.7%) and among the professional categories, doctors (58.3%) accounted for the majority of cases. Symptomatic infection was prevalent in 89.7% of cases, with most being mild. Out of 312 healthcare workers, 265 (84.9%) received at least one dose of the Covishield vaccine. Of these, 206 (77.7%) received two doses, and 41 (15.5% of vaccinated HCWs) also received a booster dose. 153 (49.1%) had a history of prior SARS-CoV-2 infection. Hospitalization was required for three unvaccinated HCWs with comorbidities, while no vaccinated HCWs required hospitalization; no deaths occurred. Conclusions: The study found that 312 healthcare workers were infected during the Omicron wave. Vaccination and prior infection did not provide complete protection against the Omicron variant. Consequently, breakthrough infections and reinfections were observed with notable frequency during this period.

 
کلیدواژه‌های انگلیسی مقاله Omicron variant, Reinfection, Breakthrough infection, Covishield vaccination, Healthcare workers
نویسندگان مقاله | Reyaz Khan
Department of Microbiology, Government Medical College, Srinagar, Jammu & Kashmir, India


| Danish Zahoor
Department of Microbiology, Government Medical College, Srinagar, Jammu & Kashmir, India


| Anjum Farhana
Department of Microbiology, Government Medical College, Srinagar, Jammu & Kashmir, India


| Masarat Jehan
Department of Anatomy, Government Medical College, Srinagar, Jammu & Kashmir, India
نشانی اینترنتی http://jommid.pasteur.ac.ir/browse.php?a_code=A-10-618-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Other
نوع مقاله منتشر شده Original article
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