| چکیده انگلیسی مقاله |
A 53-year-old male farmer presented with clinical manifestations consistent with Crimean-Congo Hemorrhagic Fever (CCHF) virus infection, reporting a recent history of tick bite. To confirm the diagnosis, molecular and serological assays were performed on four specimens collected following the onset of illness. Reverse transcription-polymerase chain reaction (RT-PCR) detected CCHF virus RNA in the initial sample, while serum immunoglobulin M (IgM) antibodies were undetectable in all specimens. Notably, a robust immunoglobulin G (IgG) antibody response was observed across all samples. The concurrence of detectable viral RNA with the presence of IgG antibodies, but the absence of IgM, in the acute phase sample suggests a potential case of CCHF virus re-infection. These findings hold significant implications for public health, particularly regarding our understanding of CCHF virus infection dynamics, diagnostics, and vaccine development strategies. |
| نویسندگان مقاله |
| Mostafa Salehi-Vaziri
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
| Tahmineh Jalali
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
| Ali Asghar Bolandakhtar
Educational and Treatment Centre, Valiasr Hospital, Kerman University of Medical Sciences, Shahrebabak, Iran
| Mehdi Fazlalipour
WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
| Ehsan Mostafavi
Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases
| Sana Eybpoosh
Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases
| Vahid Baniasadi
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
| Mahsa Tavakoli
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
| Tahereh Mohammadi
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
| Sanam Azad-Manjiri
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
| Motahareh Hosseini
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
| Zahra Fereydouni
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran
| Mohammad Mehdi Gouya
Centre of Disease Control (CDC), Ministry of Health, Tehran, Iran
| Gary P Kobinger
Département de microbiologie-infectiologie et d’immunologie, Université Laval, Quebec City, Quebec, Canada
| Mohammad Hassan Pouriayevali
Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, Tehran, Iran; Research Center for Emerging and Reemerging Infectious Disease, Pasteur Institute of Iran, Tehran, Iran
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