| The NLRP3 inflammasome has emerged as a pivotal player in the progression of cardiovascular diseases, acting as a critical mediator of inflammation and immune responses. This multi-protein complex is activated in response to various stress signals, leading to the production of proinflammatory cytokines such as IL-1β and IL-18, which are implicated in the pathogenesis of atherosclerosis, myocardial infarction, and heart failure. Recent studies have highlighted the potential of targeting the NLRP3 inflammasome as a therapeutic strategy to mitigate cardiovascular disease progression. Integrating food science and technology offers promising avenues for developing novel interventions. Nutraceuticals and functional foods rich in antiinflammatory compounds, such as omega-3 fatty acids, polyphenols, and flavonoids, have shown efficacy in modulating inflammasome activity. Advances in food processing and biotechnology can enhance the bioavailability and efficacy of these compounds, providing a complementary approach to conventional pharmacotherapy. Furthermore, understanding the interactions between dietary components and genetic predispositions may enable personalized nutrition strategies to prevent or treat cardiovascular diseases. As research continues to unravel the complexities of the NLRP3 inflammasome and its role in cardiovascular health, interdisciplinary collaborations between food scientists, technologists, and medical researchers are crucial for translating these findings into practical therapeutic advancements. |