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Research in Pharmaceutical Sciences، جلد ۲۰، شماره ۴، صفحات ۴۹۸-۵۱۰
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عنوان انگلیسی Anti-inflammatory and cytotoxic effects of Jatropha podagrica extracts on skin cancer
چکیده انگلیسی مقاله Background and purpose: Jatropha podagrica Hook . belongs to the Euphorbiaceae family, which possesses anticancer activities and is traditionally applied to treat skin diseases. No reports of J. podagrica anti-neoplastic activity on an amelanotic melanoma and associated inflammatory mediators exist. Experimental approach: The biological activities, including cytotoxic and anti-inflammatory effects of                    J. podagrica extracts, were evaluated. Key compounds in the extracts were identified using LC-MS/MS analysis. Findings/Results: The hexane extract of the root (RMH) demonstrated the highest inhibition of NO production with an IC 50 of 4.94 ± 0.25 µg/mL, followed by the ethanolic extracts of the root (RME) and stem (SME) with IC 50 values of 24.90 ± 1.06 and 25.20 ± 0.10 µg/mL, respectively. However, RMH showed cellular toxicity at 50 µg/mL, while other extracts were non-toxic up to 100 µg/mL. None of the extracts affected the concentrations of inflammatory mediators PGE 2 or TNF-α. The cytotoxic activity of SME showed an IC 50 of 5.62 ± 0.58 µg/mL, comparable to that of the anticancer drug 5-fluorouracil, with an IC 50 of 0.59 ± 0.01 µg/mL. The selectivity index of SME was >17.79, significantly higher than that of 5-fluorouracil, which was 0.08.          LC-MS/MS analysis identified two main compounds from the coumarin group: fraxetin at 5.357 min and its positional isomer tomentin at 5.943 min. Conclusion and implications: The study indicates that SME exhibits good cytotoxic activity and inhibits key cancer hallmarks such as NO production. The presence of coumarins, identified through LC-MS/MS, suggests that these compounds may play a crucial role in the extract's anticancer effects, highlighting the potential for future development as cancer therapeutics.  
کلیدواژه‌های انگلیسی مقاله Anti-inflammatory activity,Coumarins,Cytotoxicity,Jatropha podagrica,Skin cancer.
نویسندگان مقاله | Reawfang Sriyom
Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand. Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Thammasat University, Pathumthani, 12120, Thailand.


| Arunporn Itharat
Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.


| Onmanee Prajuabjinda
Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.


| Pakakrong Thongdeeying
Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.


| Srisopa Ruangnoo
Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Thammasat University, Pathumthani, 12120, Thailand.


| Sunita Makchuchit
Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Thammasat University, Pathumthani, 12120, Thailand.


| Pranporn Kuropakornpong
Master Degree of Science program (Applied Thai Traditional Medicine), Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand.


| Kanyarat Namphonsaen
Master Degree of Science program (Applied Thai Traditional Medicine), Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand.


| Perika Monkanna
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2P5, Canada.


| Neal M. Davies


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2323
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