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International Journal of Occupational Hygiene، جلد ۱۵، شماره ۳، صفحات ۳۶-۴۳
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عنوان انگلیسی Development and Prevention of Noise-induced Hearing Loss: The Role of Oxidative Stress and Antioxidants
چکیده انگلیسی مقاله Exposure to industrial, military, and other occupational noises can cause noise-induced hearing loss (NIHL), which poses significant health risks for workers but is also potentially preventable. Currently, there is no effective treatment for NIHL, as mammalian cochlear hair cells cannot regenerate once damaged. Therefore, preventing hair cell death or implementing early therapeutic intervention is essential for preserving hearing function. NIHL is a complex condition that results from multiple pathophysiological changes. Recent studies on cochlear cellular structures have revealed promising strategies for NIHL prevention through the development of protective pharmacological agents. Reduced cochlear blood flow, inflammation, and oxidative stress are recognized as key mechanisms contributing to NIHL, with oxidative stress playing a particularly critical role. This research aimed to investigate the link between oxidative stress and the onset of NIHL, as well as to explore the potential of endogenous and exogenous antioxidant defense mechanisms in its prevention.
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نویسندگان مقاله | Vida Rezaei-Hachesu
Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Shadi Naderyan Fe’li
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Rajabali Hokmabadi
Department of Occupational Health Engineering, School of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
نشانی اینترنتی https://ijoh.tums.ac.ir/index.php/ijoh/article/view/672
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