این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۵۴، شماره ۸، صفحات ۱۷۶۵-۱۷۷۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Ferroptosis-Related Genes in Gastric Cancer via Bioinformatics Analysis
چکیده انگلیسی مقاله Background: Gastric cancer (GC) ranks among the most prevalent malignancies globally, contributing significantly to both morbidity and mortality. Ferroptosis, a unique iron-dependent form of cell death, has been implicated in various cancers, including GC. This study investigated the association between ferroptosis-related genes (FRGs) and GC using bioinformatics analyses. Methods: Differentially expressed genes (DEGs) were identified using a publicly available microarray dataset. Genes associated with ferroptosis were then extracted, and their overlap with the DEGs was assessed. To gain further insights, functional enrichment analysis was performed, followed by the prediction of microRNA (miRNA) and transcription factor (TF) interactions. Additionally, a protein-protein interaction (PPI) network was constructed. Key genes were identified using the CytoHubba extension in Cytoscape, and their prognostic value was analyzed through receiver operating characteristic (ROC) curve evaluation. Results: Overall, 3242 DEGs were identified, of which 78 were ferroptosis-related (DEFRGs). These DEFRGs were enriched in pathways such as ferroptosis and pathways in cancer. Among them, hsa-miR-106a-5p and SP1 were identified as key miRNA and TF, respectively. The PPI network revealed five hub genes: TP53, MDM2, KRAS, IL6, and PTGS2. ROC curve analysis demonstrated that all hub genes have excellent prognostic value for GC. Conclusion: This study highlights the critical association between GC and ferroptosis-related genes using bioinformatics tools. These findings provide insights for future investigations and the development of targeted therapies against GC.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Reza Maddah
National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran


| Marjan Talebi
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Rouzbeh Almasi Ghale
Department of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NI-GEB), Tehran, Iran


| Fatemeh Saadati
National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran


| Saghi Noorayi
National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran


| Mahnaz Karimi
National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran


| Amir Shafie Kafraj
National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran


| Farkhondeh Pouresmaeili
1. Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences Tehran, Iran 2. Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/34625
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات