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Iranian Journal of Public Health، جلد ۵۴، شماره ۸، صفحات ۱۶۷۸-۱۶۸۸
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عنوان انگلیسی Unveiling Cadmium-Induced Cardiotoxicity: Mechanisms, Challenges, and Future Perspectives: A Narrative Review
چکیده انگلیسی مقاله We investigated the mechanisms of cadmium-induced cardiotoxicity, focusing on its pathophysiological effects, potential preventive strategies, and therapeutic interventions. We further explored approaches to mitigate long-term cardiovascular risks associated with cadmium exposure. This research analyzed the molecular and cellular pathways involved in cadmium toxicity, emphasizing oxidative stress, inflammation, endothelial dysfunction, platelet-leukocyte interactions, and cardiomyocyte damage. Experimental findings and existing literature were examined to uncover the mechanisms driving cadmium-induced cardiotoxicity and to identify potential therapeutic targets. Cadmium exposure leads to oxidative stress and inflammation, resulting in endothelial dysfunction, platelet-leukocyte activation, and thromboinflammation. It disrupts calcium signaling, elevates reactive oxygen species (ROS) production, and causes cardiomyocyte loss, ultimately impairing cardiac function. Cadmium also remodels ion channels and suppresses cardiomyocyte proliferation, intensifying its cardiotoxic effects. While current therapies focus on removing circulating cadmium, they do not address the residual cardiovascular damage caused by prior exposure. Cadmium exerts significant cardiotoxic effects through oxidative stress, inflammation, and cellular activation. Future therapeutic strategies should target these pathways, particularly the activation of platelets, leukocytes, and endothelial cells, to reduce cadmium-induced cardiovascular damage and improve long-term outcomes.
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نویسندگان مقاله | Mandana Pouladzadeh
Emergency Medicine Department, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Masoud Danjeh
Department of Cardiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Negin Yousefi Chermehini
Emergency Medicine Department, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


| Somayeh Zamanifard
Department of Cardiology, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran


| Ali Abesi
Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


| Parisa Molaee
Department of Cardiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Hadi Rezaeeyan
Asadabad School of Medical Sciences, Asadabad, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/35885
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