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Iranian Journal of Pathology، جلد ۲۰، شماره ۴، صفحات ۳۸۰-۳۸۵
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عنوان انگلیسی Prevalence of algD, pslD, and pelF Genes Involved in Biofilm Formation in Clinical MDR Pseudomonas aeruginosa Strains
چکیده انگلیسی مقاله Background & Objective: The purpose of this research was to determine the frequency of algD, pslD, and pelF genes in biofilm formation among MDR and non-MDR clinical strains of Pseudomonas aeruginosa in Khorramabad, Iran (2024).
Methods: This cross-sectional study included all Pseudomonas aeruginosa isolates collected from various clinical samples in Khorramabad teaching hospitals in 2024. After confirming the isolates and determining their antibiotic resistance patterns using the disc diffusion method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines, algD, pelF, and pslD genes were detected by PCR.
Results: The highest sensitivity was observed to imipenem (75%) and meropenem (71.3%), while the greatest resistance was recorded against ciprofloxacin, ceftazidime, and tobramycin 45 (56.25%). The frequencies of the algD, pelF, and pslD genes were 88.8, 76.3, and 96.3%, respectively. A significant association was found between the PelF and algD genes with multidrug resistance (MDR) (P<0.05).
Conclusion: The presence of multi-drug resistance (MDR) in this study indicates the need for serious measures to control infections caused by this bacterium. Further research is recommended to explore the contribution of biofilm-associated genes to the  development of multi-drug resistance (MDR).
کلیدواژه‌های انگلیسی مقاله Pseudomonas aeruginosa,biofilm,Multidrug resistance (MDR),Exopolysaccharides
نویسندگان مقاله Zahra Haghighatian |
Department of Pathology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Negar Shirani |
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran

Gholamreza Goudarzi |
Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Pegah Shakib |
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran

Fatemeh Jahani |
Department of Biology, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran

Sodabeh Zare |
Department of Biostatistics and Epidemiology, School of Health and Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_728537_4939903c4fc223dc440a0b947d1db282.pdf
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