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Iranian Journal of Pathology، جلد ۲۰، شماره ۴، صفحات ۴۵۴-۴۶۲
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عنوان انگلیسی Factors Associated with In-Hospital Mortality in Adult Patients with Community-Acquired Staphylococcus aureus Bacteremia: A Cross-Sectional Study
چکیده انگلیسی مقاله Background & Objective: Community-acquired Staphylococcus aureus bacteremia (CA-SAB) is associated with substantial morbidity, mortality, and healthcare costs. This study aimed to identify clinical and laboratory factors associated with in-hospital mortality among patients with CA-SAB.
Methods: This retrospective cross-sectional study was conducted at a tertiary referral hospital in Tehran, Iran. Adult patients with positive blood cultures for S. aureus who met CA-SAB criteria were included. Demographic, clinical, and laboratory data were collected from medical records. The primary outcome was in-hospital mortality. Univariate and multivariate logistic regression analyses were performed to assess associations with mortality.
Results: A total of 114 patients with CA-SAB were included. No significant association was observed between underlying comorbidities and mortality. Although methicillin-resistant S. aureus (MRSA) infection was associated with a higher mortality rate, this difference was not statistically significant (P = .32). Multivariate analysis revealed that older age (odds ratio [OR], 1.053; 95% CI, 1.012–1.095; P = .01), elevated C-reactive protein (CRP) levels (OR, 1.016; 95% CI, 1.005–1.028; P < .01), and lower serum albumin levels (OR, 0.249; 95% CI, 0.097–0.642; P < .01) were independently associated with in-hospital mortality.
Conclusion: Although age was not significant in univariate analysis, it emerged as a significant predictor after adjustment for other variables. Routine laboratory parameters such as CRP and albumin may serve as valuable prognostic indicators. Early identification of high-risk patients using these markers could inform timely interventions and improve outcomes in CA-SAB.
کلیدواژه‌های انگلیسی مقاله Staphylococcus aureus,bacteremia,Mortality,Community-Acquired Infections,methicillin resistance
نویسندگان مقاله Sogol Alikarami |
Pain Research Center, Neuroscience Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Ghazal Razani |
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

SeyedAhmad SeyedAlinaghi |
Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran

Arash Seifi |
Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Alireza Abdollahi |
Department of Pathology, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Nazanin Anaraki |
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Sara Ghaderkhani |
Department of Pathology, Imam Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_728588_ba13e1650df9aa33e3d7638865a0a1e8.pdf
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