این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
پژوهش‌های آسیب‌ شناسی زیستی، جلد ۲۶، شماره ۳، صفحات ۷-۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Molecular detection of dupA-positive Helicobacter pylori from dental plaque of periodontal patients: A prospective study
چکیده انگلیسی مقاله Introduction:
This study aimed to detect H. pylori genome in dental plaque samples and determine the frequency of the dupA after bacterial culture and PCR assay.
Materials and Methods:
In this prospective study, the inclusion criteria were as: age greater and equal to 20; the need for dental examination performed by a clinician, and finally no record of antibiotic uptake against H. pylori 30 days before sampling. All demographic information of included subjects such as gender, age, history of smoking, and anti-H. pylori therapy was also recorded. DNA was extracted and bacterial culturing was performed within 4 hours of sample receipt. A patient was declared positive for H. pylori when the confirmatory glmM PCR result.
Results:
Of 40 symptomatic subjects, thirty-five were H. pylori positive (87.5%). Among the H. pylori-positive subjects, 28 (80%) were dupA positive. Meantime, for the subjects in the healthy group, 15 cases were H. pylori positive, and among this population 6 patients (40%) were dupA positive (P value <0.05). According to this study, it has been shown that in both groups with a periodontal pocket depth of 3-4 mm and without this depth H. pylori was detectable in the dental plaques, but this rate was significantly higher in the patient group (P=0.023).
Conclusions:
Conclusively, the study can be the initial step in the designation of a specific bacterial gene to track the H. pylori infection and chance of associated diseases in clinical samples while discarding the endoscopic examination as the invasive method is the highest priority.
کلیدواژه‌های انگلیسی مقاله Helicobacter pylori,dupA,dental plaque,human reservoir
نویسندگان مقاله Layegheh Daliri |
Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Amin Talebi Bazminabadi |
Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

نشانی اینترنتی https://mjms.modares.ac.ir/article_19480_72d8beea4c67124fa859b63e6405da54.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات