این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
پژوهش‌های آسیب‌ شناسی زیستی، جلد ۲۲، شماره ۱، صفحات ۲۱-۲۵
عنوان فارسی اثر هایپرکلسترولمیا روی پراکنش نشانگرهای فعال‌سازی لنفوسیت‌های T خون محیطی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of hypercholesterolemia on the distribution of peripheral T lymphocyte activation markers
چکیده انگلیسی مقاله Aims: The correlation between high levels of blood lipid with the induction of some diseases indicates significant effects of hyperlipidemia and especially on the immune system, inflammatory response, and secretion of cytokines. This is due to changes in the composition of cholesterol in the cell membrane and macrophage cytoplasm, which disrupts the signaling pathway necessary for the innate immune response. The purpose of this study was to investigate the effect of on phenotype properties of T cells and the expression of its associated activation markers.
Materials & Methods: In the present experimental study 3ml of peripheral blood samples were collected from 30 patients and 30 healthy subjects. The distribution of activation markers was evaluated by Immunophenotyping with anti-CD4, CD8, CD25, and CD69 antibodies. was used and output data were analyzed using Flow Jo 10 and SPSS 16 software.
Findings: Evaluation of the activation markers located T cells of patients with showed a significant decline by 0.8% and 2% in the expression of CD25 marker and 1.92% and 2.12% in the expression of CD69 marker on CD8+ CD4+ T cells, respectively (p<0.05).
Conclusion: The changes in the phenotype properties of T cells and the decreased expression of activation markers in high-level cholesterol conditions might weaken the immune system in hyperlipidemia patients.
کلیدواژه‌های انگلیسی مقاله Hyperlipidemias,T-lymphocytes,Immunophenotyping
نویسندگان مقاله Z. Emruzi |
Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

P. Babaheidarian |
Clinical Pathology Department, Medicine Faculty, Iran University of Medical Sciences, Tehran, Iran

Gh. Ahangari |
Medical Genetics Department, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

نشانی اینترنتی https://mjms.modares.ac.ir/article_19338_f3cd9d8669d626436967d042880add4c.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات