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پژوهش‌های آسیب‌ شناسی زیستی، جلد ۲۲، شماره ۱، صفحات ۳۵-۴۰
عنوان فارسی مطالعه اثر محافظتی نانوکپسول سیاه‌دانه بر آسیب‌شناسی بافتی و سطوح اینترلوکین ۱۰ بافت ریه رت‌های در معرض NNK
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عنوان انگلیسی Study of Protective Effect of Nigella Sativa Nanocapsules on Tissue Pathology and IL-10 levels in Lung Tissues Exposed to NNK
چکیده انگلیسی مقاله Aims: It is assumed that ketone derived from tobacco (NNK) which is the most important carcinogen in tobacco modulates alveolar macrophage mediator production, such as anti-inflammatory cytokine IL-10. The aims of this study were to investigate the effect of a Nigella sativa on tissue pathology and IL-10 levels in lung tissues exposed to NNK
Materials & Methods: In this experimental study, 46 Wistar rats of supplement, supplement+NNK, NNK, solvent and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12.5 mg per kg body weight. Supplemented groups also consumed Nigella sativa Nanocapsules for 12 weeks. Levels of IL-10 in homogenized lung tissue were measured by ELISA. To analyze the data; ANOVA and Tukey test were used at a significance level of p≤005.
Findings: Exposure to NNK increased levels of IL-10 compared with the solvent group, although not statistically significant (p≥005). Meanwhile, a period of consumption of Nigella sativa Nanocapsules significantly increased levels of IL-10 in NNK + supplement and the supplement groups compared to NNK group (p=0.038, p=0.002; respectively). In addition, the effect of Nigella sativa Nanocapsules on IL-10 levels of lung tissue was shown that the levels of this variable were significantly higher than the solvent group (p=0.001).
Conclusion: Generally it could be confirmed that consumption of Nigella sativa Nanocapsules plays an important role in the inhibition of inflammation induced by NNK via Increase of IL-10 activity.
Aims: It is assumed that ketone derived from tobacco (NNK) which is the most important carcinogen in tobacco modulates alveolar macrophage mediator production, such as anti-inflammatory cytokine IL-10. The aims of this study were to investigate the effect of a Nigella sativa on tissue pathology and IL-10 levels in lung tissues exposed to NNK
Materials & Methods: In this experimental study, 46 Wistar rats of supplement, supplement+NNK, NNK, solvent and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12.5 mg per kg body weight. Supplemented groups also consumed Nigella sativa Nanocapsules for 12 weeks. Levels of IL-10 in homogenized lung tissue were measured by ELISA. To analyze the data; ANOVA and Tukey test were used at a significance level of p≤005.
Findings: Exposure to NNK increased levels of IL-10 compared with the solvent group, although not statistically significant (p≥005). Meanwhile, a period of consumption of Nigella sativa Nanocapsules significantly increased levels of IL-10 in NNK + supplement and the supplement groups compared to NNK group (p=0.038, p=0.002; respectively). In addition, the effect of Nigella sativa Nanocapsules on IL-10 levels of lung tissue was shown that the levels of this variable were significantly higher than the solvent group (p=0.001).
Conclusion: Generally it could be confirmed that consumption of Nigella sativa Nanocapsules plays an important role in the inhibition of inflammation induced by NNK via Increase of IL-10 activity.
کلیدواژه‌های انگلیسی مقاله Nigella sativa,Nanocapsules,IL-10,NNK,Histologic Structure
نویسندگان مقاله A. Barzegari |
Department of physical education, Payame Noor University, Tehran, IRAN.

Sh. Mirdar |
Department of Sport Physiology, Faculty Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Iran

نشانی اینترنتی https://mjms.modares.ac.ir/article_19340_daa66faceefb746a71184f9689e94297.pdf
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