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عنوان فارسی مقایسه ایمنی‌زایی واکسن تجاری هپاتیت B ایران، واکسن فرموله‌شده در ادجوانت روغنی مونتانید ۷۲۰ و واکسن فندریکس شرکت GSK در موش‌های بالب/‌سی
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عنوان انگلیسی Comparison of Immunization of Iran's Hepatitis B Vaccine, Vaccine Formulated in Montanide ISA 720 Aadjuvant and Fendrix Vaccine from GSK Company on the Balb/C Mice
چکیده انگلیسی مقاله Aims: Vaccination is the only approach to prevent hepatitis B virus infection, But some people do not get a good immune response to the commercial hepatitis B vaccine. The purpose of the present study was to compare the immunization of Iran's Hepatitis B vaccine, vaccine formulated in montanide ISA 720 adjuvant and Fendrix vaccine from GSK company on the Balb/c mice.
Materials and Methods: In this experimental study, 54 female inbred Balb/c mice were injected in three different formulations of vaccine subcutaneously with two-week intervals. Quantitative amount of IFN-γ, IL-4, and IL-2 cytokines and the IFN-γ/IL-4 ratio from spleen cell culture Supernatant and the anti-HBs Ag antibody level After each injection withBlood sampling were evaluated by ELISA method. Data were analyzed by Graphpad prism 6.1 software via one way analysis of variance.
Findings: The vaccine recipient groups did not show significant differences in IFN-γ, IL-2 cytokines and IFN-γ/ IL-4 ratio (p>0.05). Iranian commercial vaccine significantly increased the cytokine IL-4 in comparison with the Fendrix and HBs-MON720 groups (p<0.05). Antibody responses after the first and second injection of Fendrix and HBs-MON720 showed a significant increase in comparison with the HBS-ALUM group (p<0.05), but no significant difference was observed after the third injection (p>0.05).
Conclusion: Cytokine responses in The Fendrix vaccine and HBs-MON720 vaccine are partly similar to the Iran's Hepatitis B vaccine but after two injections, Fendrix and HBs-MON720 vaccine showed a higher antibody response.
کلیدواژه‌های انگلیسی مقاله Alum Adjuvant,Montanide 720,Hepatitis B Vaccine,Fendrix Vaccine
نویسندگان مقاله M. Mirzaee |
Microbiology Department, Science & Technology Faculty, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

S. Haghighat |
Microbiology Department, Science & Technology Faculty, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran

M. Mahdavi |
Recombinant Vaccines Research Center, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://mjms.modares.ac.ir/article_19317_63654968e4a45645c48aec7ca9e39554.pdf
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