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Addiction and Health، جلد ۱۷، شماره ۱، صفحات ۱-۷
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عنوان انگلیسی Seizures as an Adverse Effect of Pregabalin Consumption: A Systematic Review
چکیده انگلیسی مقاله Background: Pregabalin (PGB), a gabapantinoid drug, which is commonly prescribed by physicians and some patients abuse it,
can lead to seizure. Pregabalin-induced seizures (PGBIS) and their risk factors were systematically reviewed.
Methods: The databases were searched from January 1, 2011, to August 1, 2022. Studies that reported PGBIS were included. The
records were assessed according to the PRISMA-P protocol.
Results: From a total of 224 records, 11 studies were included, comprising four cross-sectional studies and seven case reports. The
data from the cross-sectional studies were notably limited. Seven studies documented nine cases (five females and four males),
with a median age of 51 years (ranging from 16 to 65). PGB was used for therapeutic purposes, abuse, and suicide attempts. One
case had kidney dysfunction. A significant number of cases used PGB with other drugs. There was no difference between the
ingested dose of PGB in men (2700 and 4200 mg) and women (3000, 1200, 3825, and 1200 mg). All cases had normal renal
function, except for one case.
Conclusion: PGBIS is not common. However, it was reported for all purposes of PGB consumption. No specific risk factor for
PGBIS was found. It was more commonly reported in females, patients who consumed high doses of PGB (>1200 mg), patients
who ingested multiple drugs, and patients with renal insufficiency. The dosages used for therapeutic purposes were much lower
than in the other two groups
کلیدواژه‌های انگلیسی مقاله Pregabalin,seizures,Neurotoxicity syndrome,Adverse effect
نویسندگان مقاله Zahra Oskouei |
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran,

Mohammad Moshiri |
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Amene Raouf-Rahmati |
Immunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ahmad Nemati |
Community Medicine Department, Mashhad University of Medical Sciences, Mashhad, Iran

Mehri Bemani Neaeni |
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Hamid Jomepour |
Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Ali Roohbakhsh |
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran,

Zahra Salmasi |
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Leila Etemad |
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی https://ahj.kmu.ac.ir/article_92529_c73405141f3fe3a928a78c58da5f4f56.pdf
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