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Addiction and Health، جلد ۱۷، شماره ۱، صفحات ۱-۷
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عنوان انگلیسی Association of CREB1 (rs2253206) and BDNF (rs6265) Polymorphisms with Implementation Intentions Treatment Response in Smoking Reduction
چکیده انگلیسی مقاله Background: Previous studies have shown that implementation intentions are moderately effective in reducing smoking among
smokers, but the factors determining its effectiveness are unclear. CREB1 (rs2253206) and BDNF (rs6265) polymorphisms have
been proposed as the genes involved in addictive behaviors; therefore, we investigated their association with smokers’ responses
to implementation intentions psychotherapy.
Methods: This clinical trial was conducted on smoking male students at Tehran University and Shahid Beheshti University.
The research sample was 78 smoking students who smoked at least seven cigarettes weekly. All of the participants received an
implementation intentions intervention session. Their smoking rates were measured before and after the intervention, and all
of them were genotyped for CREB1 (rs2253206) and BDNF (rs6265) using PCR-RFLP. The prospective-retrospective memory
questionnaire (PRMQ) was used to evaluate the prospective memory (PM). Analysis of covariance (ANCOVA) and simple linear
regression were used to analyze the data using SPSS version 26 at a significance level of 0.05.
Results: The results showed that implementation intentions affect smoking reduction (t = 4.44, P = 0.001). Data analysis showed
no relationship between these two SNPs and treatment response. Also, no association was observed between these SNPs and PM.
However, regression analysis showed that PM could predict the response to treatment (R2 = 0.10, F = 12.15, P = 0.001).
Conclusion: Implementation intentions can be suitable for reducing smoking. Studying the effect of genetic factors on
psychotherapy in larger samples could be an effective way to individualize psychological treatments in reducing smoking,
including implementation intentions.
کلیدواژه‌های انگلیسی مقاله smoking cessation,Genetic Polymorphisms,Implementation Intentions
نویسندگان مقاله Neda Yadegari |
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mehdi Tehrani-Doost |
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Ali Yoonesi |
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Sareh Asadi |
Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Reza Majdzadeh |
Department of Epidemiology and Biostatistics, School of Public Health and Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://ahj.kmu.ac.ir/article_92703_c6adbfee5d91742ddbe15940fa61b8c1.pdf
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