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Nanomedicine Journal، جلد ۱۲، شماره ۴، صفحات ۷۳۰-۷۴۵
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عنوان انگلیسی QbD assisted development and optimization of composite guar gum silver nanoparticle-based posaconazole hydrogel
چکیده انگلیسی مقاله Objective(s): This study aimed to enhance the bioavailability and optimize a composite silver nanoparticle-based Posaconazole hydrogel using a Quality by Design (QbD) approach. A Box-Behnken design was employed as an independent quadratic model within the QbD framework. The primary goals were to improve antifungal efficacy, achieve controlled drug release, and ensure formulation stability and safety.Materials and Methods: A systematic QbD strategy was applied, involving the identification of Critical Quality Attributes (CQAs) and Critical Process Parameters (CPPs) to develop a robust formulation. Silver nanoparticles were incorporated into the hydrogel matrix,and Posaconazole, the active pharmaceutical ingredient, was added. The formulation parameters were optimized using a Design of Experiments (DoE) approach, specifically the response surface methodology (RSM) via Box-Behnken design. The optimized hydrogel w:as char:acterized using Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and invitro release studies.Results: The optimized hydrogel exhibited an enhanced pharmacokinetic profile, sustained drug release, and improved quality attributes. Stability was confirmed through accelerated stability studies. Remarkably,invitro release studies demonstrated a 90.35% drug release within twelve minutes.Conclusion: The Box-Behnken optimization technique successfully developed a silver nanoparticle-based Posaconazole hydrogel. The formulation showed significant potential for improved therapeutic efficacy in antifungal treatment.
کلیدواژه‌های انگلیسی مقاله Silver, Nanoparticles, Hydrogel, optimization, Antifungal agent
نویسندگان مقاله | Anushree Piplonia
Post Graduate Scholar, IPS Academy, College of Pharmacy, Indore, India


| Upendra Bhadoriya
Associate Professor, IPS Academy, College of Pharmacy, Indore, India


| Nitin Dubey
Professor, IPS Academy, College of Pharmacy, Indore, India
نشانی اینترنتی https://nmj.mums.ac.ir/article_26339.html
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