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Dental Research Journal، جلد ۲۲، شماره ۹، صفحات ۰-۰
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عنوان انگلیسی Comparative study of E‑cadherin expression between reticular, erosive oral lichen planus and lichenoid lesions
چکیده انگلیسی مقاله Background: Accurate and early diagnosis of dysplastic lesions is crucial for successful treatment. A decrease in E‑cadherin expression has been observed in dysplastic lesions and tumors. Therefore, the aim of this study was to investigate the expression of E‑cadherin, a cell membrane adhesive protein involved in tissue structure and differentiation, in oral reticular lichen planus, erosive lichen planus, and lichenoid lesions. Materials and Methods: This descriptive cross‑sectional study was conducted on 65 oral samples (20 reticular lichen planus, 20 erosive lichen planus, and 20 lichenoid lesions, with 5 samples of healthy mucosa), to evaluate the expression of E‑cadherin using immunohistochemical methods. Data were analyzed using SPSS software (version 25), descriptive statistics, Chi‑square tests, and Fisher’s exact tests, with a significance threshold set at P < 0.05. Results: The majority of patients were female (72.3%) and primarily in the sixth and seventh decades of life (49.2%). A significant difference was observed between the studied groups regarding staining status (P = 0.038), with erosive lichen planus showing the highest frequency of alterations in E‑cadherin expression (45%). In addition, a significant difference was noted between staining status and lesion location (P = 0.004), with the highest frequency of E‑cadherin expression changes occurring in buccal mucosal samples (30%). Conclusion: E‑cadherin expression in erosive lichen planus is significantly lower than in healthy tissue, reticular lichen planus, and lichenoid lesions. Given the similar reduction observed in squamous cell carcinoma samples, evaluating E‑cadherin expression may aid in the early recognition of malignant changes. Key Words: Cadherins, immunohistochemistry, lichen planus, oral mucosa     Highlight Forooz Keshani:  Pubmed , Google Scholar
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نویسندگان مقاله | Laleh Maleki


| Gholamreza Jahanshahi


| Forooz Keshani


| Samira Fotoohi Ashiin


نشانی اینترنتی http://drj.mui.ac.ir/index.php/drj/article/view/2658
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زبان مقاله منتشر شده en
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