این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Physics، جلد ۲۲، شماره ۳، صفحات ۱۳۰-۱۴۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی A Review of Normal Brain Aging: Detailed Study of Physiological Changes, Risk Factors, and Neuroimaging Techniques
چکیده انگلیسی مقاله Introduction: The process of brain aging is a complex phenomenon that can manifest in a number of ways, including normal, pathological, and accelerated aging, each influenced by modifiable factors such as sex and lifestyle. Subtle, preclinical alterations, including iron accumulation, proteostasis disruption, and inflammation, often precede overt clinical manifestations of cognitive decline, highlighting the need for early detection and intervention.Material and Methods: This review examines the neuropathological mechanisms of age-related cognitive decline, integrating current knowledge on the interplay of genetic, environmental, and lifestyle factors. Advanced neuroimaging techniques, particularly magnetic resonance imaging (MRI) and positron emission tomography (PET) offer powerful tools for investigating the complex biological and biochemical dynamics of the aging brain. Quantitative Susceptibility Mapping (QSM), a novel MRI technique, provides precise quantification of tissue magnetic susceptibility, enabling detailed assessment of iron deposition and myelin content, both crucial factors in age-related brain changes.Results: We explore the diagnostic potential of QSM and other advanced neuroimaging techniques for identifying early biomarkers of brain aging and predicting cognitive trajectories. This research indicates that the accumulation of non-heme iron is a primary contributor to neuronal death in brain aging. This conclusion is supported by QSM studies, which have validated the role of iron in this process.Conclusion: By integrating mechanistic understanding with practical prevention strategies, this research indicates that the accumulation of non-heme iron is a primary contributor to neuronal death in brain aging. Additionally, the literature suggests that dietary and physical activity interventions may beneficially mitigate neurodegeneration associated with aging.
کلیدواژه‌های انگلیسی مقاله magnetic resonance imaging, Aging, Neuroimaging, Iron, Brain
نویسندگان مقاله | Erfan Hasanpour-khalesi
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Farzane Nikparast
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Zohreh Ganji
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Nazanin Nahofteh
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran


| Hoda Zare
Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijmp.mums.ac.ir/article_26747.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات