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Iranian Heart Journal، جلد ۲۶، شماره ۴، صفحات ۶-۱۴
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عنوان انگلیسی Renal Function in Children With Congenital Heart Disease After Cardiopulmonary Bypass
چکیده انگلیسی مقاله Background: Kidney dysfunction is a known complication in children with congenital heart disease (CHD). While numerous studies have explored risk factors for nephropathy in this population, research specifically comparing renal function before and after open-heart surgery remains limited. This study aimed to evaluate kidney function in children with CHD both before and after cardiopulmonary bypass and open-heart surgery.   Methods: This prospective observational study included children with CHD, aged 1 month to 5 years, who underwent open-heart surgery. Demographic information and serum levels of creatinine, urea, albumin, and glomerular filtration rate (GFR) were collected at 24 hours pre-surgery and at 24, 48, and 72 hours, and 1 week post-surgery. Data analysis and comparisons were performed based on the type of CHD (cyanotic versus acyanotic).   Findings: Twenty-six cyanotic and 40 acyanotic children with CHD, with a mean age of 16.34 ± 15.50 months, were included in the study. Serum levels of creatinine, urea, and albumin significantly increased 24 hours after the operation (P <0.05). GFR significantly decreased at 24 and 48 hours postoperatively (P <0.05). Moreover, 72 hours after the operation, creatinine levels were significantly higher in the cyanotic group than in the acyanotic group (P =0.007). At 24 hours (P =0.02) and 72 hours (P =0.05) postoperatively, higher mean urea levels were observed in the cyanotic group. Patients undergoing surgeries lasting over 60 minutes had higher serum urea levels than those with shorter surgical durations (P =0.05).   Conclusions: These results suggest that renal function indices were altered during the first two days following open-heart surgery in children with CHD. (Iranian Heart Journal 2025; 26(4): 6-14)
کلیدواژه‌های انگلیسی مقاله Congenital heart disease,Kidney Function,Open-heart surgery,Cardiopulmonary bypass
نویسندگان مقاله Negar Saadaat Haidari |
Student Research Committee, Faculty of Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, IR Iran.

Saeed Abtahi |
Faculty of Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, IR Iran.

Mahmood Hosseinzadeh Maliki |
Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran.

Farhad Samadieh |
Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran.

Fereshteh Najafi |
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IR Iran.

نشانی اینترنتی https://journal.iha.org.ir/article_230985_9622405cf194c11fba5426ff7e3ca7bd.pdf
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