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Iranian Heart Journal، جلد ۲۶، شماره ۴، صفحات ۳۴-۴۵
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عنوان انگلیسی Heart Failure With Preserved Left Ventricular Ejection Fraction in Chronic Kidney Disease
چکیده انگلیسی مقاله Background: Chronic kidney disease (CKD) can lead to left ventricular (LV) systolic and diastolic dysfunction. Cardiovascular disease is a primary cause of mortality in this patient population. This study aimed to use the H2FPEF score to identify patients with CKD who have a high probability of heart failure with preserved ejection fraction (HFpEF).   Methods: We included 100 patients with CKD stages III through V and dyspnea suggestive of heart failure with an ejection fraction greater than 50%. All patients were evaluated for demographic data, CKD, and cardiovascular disease risk factors. Comprehensive echocardiography was performed, and LV global longitudinal strain (GLS) was assessed in patients in sinus rhythm. The H2FPEF score was calculated to predict the probability of HFpEF, with scores interpreted as follows: less than 2, unlikely; 2 to 5, intermediate; and 6 or greater, high.   Results: The probability of HFpEF was high in 29% of patients, intermediate in 66%, and low in 5%. Patients with a high probability of HFpEF had significantly worse LV GLS (–14.08 ± 1.084 vs –15.07 ± 1.24%; P = 0.01) and lower hemoglobin levels (9.71 ± 0.66 vs 10.7 ± 1.33 g/dL; P < 0.001). The H2FPEF score correlated positively with LV GLS (r = 0.406; P < 0.001). A hemoglobin level of 9.7 g/dL or less predicted a high H2FPEF score with an overall accuracy of 72.6%.   Conclusions: Using the simple, noninvasive H2FPEF score, we found that nearly one-third of patients with CKD had a high probability of HFpEF. LV systolic function declined as the H2FPEF score increased. Hemoglobin level was an independent predictor of a high probability of HFpEF. (Iranian Heart Journal 2025; 26(4): 34-45)
کلیدواژه‌های انگلیسی مقاله Cardio-renal syndrome,Heart failure,Left ventricular diastolic dysfunction,Renal anemia,Systolic dysfunction
نویسندگان مقاله Tarief Sallam |
Ain Shams University, Faculty of Medicine, Cardiology Department, Egypt.

Salah Eldin Hamdy El-Demerdash |
Ain Shams University, Faculty of Medicine, Cardiology Department, Egypt.

Wael Elkilany |
Ain Shams University, Faculty of Medicine, Cardiology Department, Egypt.

Mohamed Saeed Hassan |
Ain Shams University, Faculty of Medicine, Internal Medicine, And Nephrology Department. Cairo, Egypt.

Islam Bastawy |
Ain Shams University, Faculty of Medicine, Cardiology Department, Egypt.

نشانی اینترنتی https://journal.iha.org.ir/article_230989_d4361503f002d36e5d4c2d1f1b434f9b.pdf
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