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Asia Pacific Journal of Medical Toxicology، جلد ۱۴، شماره ۳، صفحات ۷۹-۸۵
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عنوان انگلیسی Clinicoepidemiological Pattern of Lithium Poisoning: Comparison of Two Decades in Tehran, Iran
چکیده انگلیسی مقاله Background: Lithium has been identified as a substance of significant toxicological concern, with the potential to inflict permanent damage to the central nervous system (CNS). This study examined cases of lithium poisoning over a period of ten years and compared them with cases from the previous decade. Methods: This cross-sectional and retrospective study was conducted on patients with lithium poisoning. The study population comprised 491 patients. Information regarding the patients was retrieved from the hospital archives using a checklist. Subsequent to discharge, patients were monitored for post-operative outcomes. Subsequent to the completion of the study, a comparison was made between the results obtained and those from the previous decade.Results: Among the 491 patients (mean age 33.6±15.1 years, 65% female) included in the study, 75.6% exhibited reduced systolic blood pressure. Lithium levels exhibited a substantial decrease following dialysis (p=0.016). The mortality rate was documented to be 1.6%. During subsequent follow-up, 0.4% of the subjects resumed lithium treatment, 1.8% attempted suicide, and 15.2% consulted a psychiatrist. It is noteworthy that cases of poisoning have increased fourfold over the past decade (P<0.001). Patients who consumed more than 40 grams of the drug demonstrated a substantial decrease in the primary outcome (P=0.021). The proportion of hospitalizations lasting over two days decreased from 50% to 20.4% (P<0.0001).Conclusion: The identification of lithium toxicity cases is facilitated by epidemiological data, thereby enabling a targeted management approach. A multifaceted approach is imperative to minimize toxicity risks. This approach should include the implementation of restricted re-prescription for suicidal use, stringent pharmacy controls, comprehensive family education on interactions, and regular renal monitoring.
کلیدواژه‌های انگلیسی مقاله Toxicity, Lithium, Epidemiological Study, Poisoning, Decade
نویسندگان مقاله | Sara Zarei
Tehran Medical Sciences Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran


| Maral Ramezani
Department of Pharmacology, School of Medicine, Arak University of Medical Sciences, Arak, Iran|Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran


| Saeed Akbarzadeh Kolahi
Department of Pharmacology and Toxicology, Tehran Medical Sciences Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran


| Shahin Shadnia
Toxicological Research Center, Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Loghman Hakim Hospital, Tehran, Iran


| Babak Mostafazadeh
Toxicological Research Center, Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Loghman Hakim Hospital, Tehran, Iran


| Peyman Erfan Talab Evini
Toxicological Research Center, Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Loghman Hakim Hospital, Tehran, Iran


| Mitra Rahimi
Toxicological Research Center, Department of Clinical Toxicology, Shahid Beheshti University of Medical Sciences, Loghman Hakim Hospital, Tehran, Iran
نشانی اینترنتی https://apjmt.mums.ac.ir/article_26763.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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