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Analytical and Bioanalytical Electrochemistry، جلد ۱۷، شماره ۷، صفحات ۵۶۸-۵۸۲
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عنوان انگلیسی Electromembrane Extraction of Nilotinib using Green Agarose-Based Membrane Modified with a Deep Eutectic Solvent of Choline Chloride and Methacrylic Acid
چکیده انگلیسی مقاله A novel and eco-friendly approach is introduced for the quantification of nilotinib in biological samples, employing gel-based electromembrane extraction (G-EME) coupled with fluorescence detection. In this method, a deep eutectic solvent (DES) composed of choline chloride and methacrylic acid (ChCl–MAA) was incorporated into agarose membranes (AG@DESChCl–MAA) to enhance extraction performance. The inclusion of DES significantly improved the conductivity, selectivity, and migration efficiency of nilotinib across the membrane. This system offers several advantages, including simplicity of operation, low cost, portability, and the elimination of toxic organic solvents. The developed method demonstrated good precision, with intra- and inter-day relative standard deviations (RSDs) of 6.5% and 8.6%, respectively. A linear calibration curve was obtained in the concentration range of 0.65 to 10.0 mg·L⁻¹, with a detection limit (LOD) of 0.20 mg·L⁻¹. These results confirm the potential of the AG@DESChCl–MAA-based G-EME system as a sensitive, green, and cost-effective alternative for nilotinib analysis in complex matrices.
کلیدواژه‌های انگلیسی مقاله Agarose membrane,deep eutectic solvent,Fluorescence detection,Gel electromembrane extraction,Nilotinib
نویسندگان مقاله Elaheh Arabi |
Department of Chemistry, Faculty of Science, University of Birjand, Birjand, South Khorasan, P.O. Box 97175/615, Iran

Ali Zeraatkar Moghaddam |
Department of Chemistry, Faculty of Science, University of Birjand, Birjand, South Khorasan, P.O. Box 97175/615, Iran

Majid Kalate Bojdi |
Department of Chemistry, Faculty of Science, University of Birjand, Birjand, South Khorasan, P.O. Box 97175/615, Iran

نشانی اینترنتی https://www.abechem.com/article_729835_5f957f63e16a82c30563fd56e703f561.pdf
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