این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Fertility and Sterility، جلد ۱۹، شماره ۴، صفحات ۳۵۳-۳۵۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Association of Interleukin-33 with Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis Study
چکیده انگلیسی مقاله Background: Recurrent pregnancy loss (RPL) is a condition in which a woman experiences two or more consecutive
miscarriages before reaching 20 weeks of gestation. The present study was designed to explore the potential link
between the interleukin (IL)-33 and RPL. To achieve this goal, we conducted a comprehensive search across the ISI,
PubMed, Embase, and Scopus databases.
Materials and Methods: We reviewed studies that examined the relationship between specific IL-33 polymorphisms
and RPL using the appropriate keywords. The comparator in our study consisted of a control group that included
women without RPL. This group was used to assess the differences in genetic polymorphisms and IL-33 serum levels
compared to women who experienced RPL. We analyzed the collected data using a random-effects model in STATA
(version 14). Five case-control studies were eligible, yielding a total sample size of 1,831 participants (891 cases and
940 controls).
Results: The results revealed a significant association between the GG genotype of IL-33 polymorphisms rs16924159
and rs1929992 [odds ratio (OR)=0.72, 95% confidence intervals (CI)=0.51-1.02, I2=58.2, P=0.068] and RPL. The
presence of the GG genotype of IL-33 polymorphisms rs16924159 and rs1929992 in women was associated with a
0.72-fold increased risk of RPL. Additionally, no statistically significant correlation was noted between IL-33 GA
(OR=1.19, 95% CI=75-1.88, I2=80.7, P=0.001) and AA (OR=1.02, 95% CI=0.81-1.29, I2=71.8, P=0.029) genotypes
and RPL. Analysis of IL-33 serum levels indicated a significant association with RPL (OR=-0.45, 95% CI=-0.67-(-
0.23), I2=57.3, P=0.128).
Conclusion: Our findings demonstrate an association between the GG genotype of IL-33 polymorphisms and an increased
risk of RPL. Moreover, higher serum levels of IL-33 are likely protective against RPL.
کلیدواژه‌های انگلیسی مقاله IL-33,Polymorphism,Recurrent Pregnancy Loss,rs16924159,rs1929992
نویسندگان مقاله Maryam Mazloomi |
Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Roza Baharishargh |
Department of Health Education, School of Medicine, Tarbiat Modares University, Tehran, Iran

Mohammad Iman Shishesaz |
School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Niousha Jamshidnezhad |
Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences, Tehran, Iran

Mina Ataee |
Department of Obstetrics and Gynecology, Social Determinants of Health, Research Center, School of Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran

نشانی اینترنتی https://www.ijfs.ir/article_719447_d6a2f6243cf60dcdd3aa62c23dd3af89.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات