| چکیده انگلیسی مقاله |
Background: Gastric cancer (GC) is the most common cancer among Iranian men. This study aimed to investigate the association between early and late lifestyle risk factors and GC among the Iranian population.
Methods: A hospital-based case-control study recruited gastric cancer (GC) patients from the Cancer Institute in 2010-2012. Controls were healthy visitors to be frequency-matched based on sex, age, and residential place and were not visiting the oncology wards. We collected exposure to various risk factors before the diagnosis in patients and prior to the interview in controls. Additionally, we obtained information on socioeconomic factors during childhood. Logistic regression models were employed to estimate the odds ratio (OR) and 95% confidence intervals (CI) for various potential risk factors.
Results: The study included a total of 212 GC patients and 287 controls. The average age of cases was 60.2 years, and controls were 53.48. Participants with a family history of GC had a 3.8-fold higher risk of GC than those without a family history (OR=3.98, 95% CI 1.86, 8.50). In addition, the odds of GC was significantly higher in cigarette smokers compared to non-smokers (OR=1.98, 95% CI 1.01-3.46). We observed an inverse association between GC by education (P trend <0.001). Individuals reported coffee consumption had a lower risk of GC (OR=0.45, 95% CI: 0.26, 0.77) as compared to non-coffee users. The study found that individuals with medium (OR=0.45, 95% CI 0.23-0.87) and high (OR=0.33, 95% CI: 0.45-0.71) intake of vegetables and high intake of fruit (OR=0.43, 95% CI 0.45-0.71) had lower odds of GC, while higher consumption of red meat (OR=4.33, 95% CI 2.15-8.77) had higher odds of GC. Analysis of factors related to the childhood period showed that lack of access to tap water increased the odds of GC compared to using tap water (OR: 3.35, 95% CI: 1.74, 6.44). We did not observe any significant associations between helicobacter pylori infection, opium use, waterpipe smoking, alcohol consumption, obesity, and other early life risk factors and the risk of GC.
Conclusion
The occurrence of GC is influenced by several factors, including family history of GC, dietary habits, and socioeconomic status during both childhood and adulthood. |
| نویسندگان مقاله |
| Kazem Zendehdel
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
| Maryam Hadji
1. Health Sciences Unit, Faculty of Social Sciences, Tampere University, Tampere, Finland
| Fatemeh Toorang
2. Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
| Neda Amni
Northwell Health, North Shore/Long Island Jewish, Department of Surgical Oncology, NYC, USA
| Fatemeh Mirfazli
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
| Sourabh Zamani
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
| Elham Kamlai-Hakim
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
| Mahsa Fithian
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
| Bahareh Sasanfar
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
| Rana Daroudi
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
| Fatemeh Shakeri
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
| Farin Kamangar
Cancer Research Center, Cancer Institute, Tehran University Medical of Sciences, Tehran, I.R. Iran
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