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Middle East Journal of Digestive Diseases، جلد ۱۷، شماره ۳، صفحات ۲۰۹-۲۱۳
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عنوان انگلیسی The Correlation between NTCP rs2296651 Variant and Risk of Hepatitis B, Cirrhosis, and Hepatocellular Carcinoma in Iranian Population
چکیده انگلیسی مقاله Background: Millions of people are suffering from different types of liver diseases worldwide. Hepatitis B, cirrhosis, and hepatocellular carcinoma (HCC) are the leading causes of death caused by the hepatitis B virus (HBV). HBV needs to interact with the sodium taurocholate co-transporting polypeptide (NTCP) to enter the cytoplasm of the hepatocyte. single nucleotide polymorphism (SNP) with rs2296651 (Ser267Phe, S267F, G>A) variation in the NTCP has been investigated as a reverse association with the function of NTCP and entry of HBV into the cell in the Asian population. We investigated the relationship between the NTCP rs2296651 variant and HBV infection, liver cirrhosis, and HCC in the Iranian population. Methods: Whole blood DNA of 50 healthy individuals as a control group and 90 patients (HBV, cirrhosis, and HCC) were extracted, and the tetra Amplification Refractory Mutation System Polymerase Chain Reaction (tetra-ARMS PCR) was done to identify the genotypes of the samples. Results: Based on our analytical tests using SPSS software, there was a positive and significant association between NTCP rs2296651 in the control group and cirrhosis (P=0.002), as well as between cirrhosis and HBV (P<0.001). However, there was a negative relationship between cirrhosis and HCC (P=0.003). Conclusions: The NTCP rs2296651 variant may confer resistance to HBV infection in the Iranian population.
کلیدواژه‌های انگلیسی مقاله Hepatitis B, Cirrhosis, Hepatocellular carcinoma, Sodium taurocholate co-transporting polypeptide (NTCP), rs2296651
نویسندگان مقاله | Hassan Akrami
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.


| Mohammad Reza Fattahi
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.


| Mastaneh Zeraatiannejad
2Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.


| Jamal Sarvari
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.


| Yousef Nikmanesh
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.


| Seyedeh Azra Shamsdin
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Zahra Mansourabadi
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran


| Saeid Amirizadeh Fard
Department of Biology, College of Sciences, Shiraz University, Shiraz 71467-13565, Iran.


| Nazanin Gohari


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/3209
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