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Iranian Journal of Dermatology، جلد ۲۸، شماره ۳، صفحات ۲۱۵-۲۲۲
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عنوان انگلیسی Non-thermal CO2 laser therapy (NTCLT) application for immediate pain relief of chronic graft-versus-host disease-(cGVHD)associated oral lesions: a case report
چکیده انگلیسی مقاله Patients who undergo allogeneic hematopoietic stem cell transplantation (HSCT) may experience oral complications related to chronic graft-versus-host disease (cGVHD), which can significantly reduce patients’ quality of life. The immediate pain- relieving effect of Non-thermal CO2 laser therapy (NTCLT), a novel and non- invasive photobiomodulation approach, has shown immediate pain-relieving effects in various painful oral lesions. This study aims to evaluate the palliative effects of a single session of NTCLT on the oral lesions of a patient with cGVHD. We present the case of a 16-year-old male with a history of acute myeloid leukemia (AML) and cGVHD following allogeneic HSCT. He was referred to our laser clinic for pain management associated with his painful oral cGVHD lesions using NTCT. The CO2 laser (set at 1 watt power) was irradiated through a thick layer of a completely transparent gel with a high-water content, while the surface of the lesion was scanned with a defocused handpiece with rapid circular motion of the handpiece. The patientexperienced immediate and marked pain relief following NTCLT, without any visible thermal adverse effects. The procedure was painless, and no anesthesia was required. This report proposes that NTCLT could be a promising, non-invasive and safe intervention for rapid pain relief in oral cGVHD lesions. However, further research is necessary to confirm its efficacy and safety in this clinical context  
کلیدواژه‌های انگلیسی مقاله bronchiolitis obliterans syndrome,oral ulcer,pain clinics,Non-Thermal CO2 Laser Therapy (NTCLT),Low-Level Light Therapy
نویسندگان مقاله Nasrin Zand |
Department of Medical Laser, Medical Laser Research Center, Yara institute, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran

Amir Abbas Hedayati Asl |
Pediatric Hematologist & Oncologist, Stem Cell Biology and Technology Department, Cancer Personalized Medicine Program, Royan Institute, Tehran, Iran

Simin Sarrafi |
Dermatologist, Private practice, Tehran, Iran

نشانی اینترنتی https://www.iranjd.ir/article_227031_f729bcf6c2fadfc0c90d1d599d9d41b9.pdf
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