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Iranian Journal of Public Health، جلد ۵۴، شماره ۹، صفحات ۲۰۰۵-۲۰۱۴
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عنوان انگلیسی Metabolomics-Based Diagnosis of Medullary Thyroid Cancer: A Plasma 1H NMR Approach
چکیده انگلیسی مقاله Background: Medullary thyroid cancer (MTC) is a rare neuroendocrine malignancy, accounting for 5-10% of all thyroid cancer cases. The precise molecular processes driving MTC remain largely elusive. We aimed to conduct a pilot study analyzing plasma metabolic profiles of MTC patients to uncover disruptions in metabolic pathways that may contribute to MTC tumorigenesis. Methods: Proton nuclear magnetic resonance (1H-NMR) spectroscopy was performed to screen metabolic changes in plasma samples from MTC patients (n=16) and healthy subjects (n=12). Multivariate and univariate analyses were applied using MetaboAnalyst and SIMCA software. Results: A total of 30 compounds were identified, of which three metabolites—glycerol, isobutyric acid, and valine—showed significant differences between MTC patients and the control group (P<0.05). Conclusion: The findings from this study contribute to the current understanding of MTC metabolism and suggest that the NMR-based metabolomics approach can provide a metabolic pattern of MTC, potentially improving diagnostic procedures.
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نویسندگان مقاله | Khadijeh Saeidi
Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran


| Mehdi Hedayati
Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Monireh Movahedi
Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran


| Maryam Sadat Daneshpour
Department of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/36196
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