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Iranian Biomedical Journal، جلد ۲۹، شماره ۴، صفحات ۲۲۸-۲۳۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Apoferritin-Functionalized with Wheat Germ Agglutinin and Loaded with Antibiotic for Targeting Bacteria
چکیده انگلیسی مقاله
Background: The selective delivery of drugs to their targets prevents their possible side effects; hence, the development of selective transport systems is considered extremely promising. In the present study, we aimed to develop a drug delivery system for targeting bacteria.
Methods: Functionalization of apoferritin with WGA, as a bacteria-recognizing lectin, was conducted. Afterwards, the complex was loaded with ampicillin. The affinity of the conjugate to Gram-positive bacteria, B. subtilis, was evaluated by anisotropic AgNPs conjugated with this complex, and its interaction with the bacteria was also assessed.
Results: The drug-delivery capabilities of the composite were evaluated. Results from the disk diffusion assay revealed that its bactericidal activity is 10-fold greater compared to free antibiotics. The effectiveness of the bactericidal effects of ampicillin-loaded ferritin was also confirmed in whole blood.
Conclusions.  Lectin-conjugated and ampicillin-loaded apoferritin can be considered as effective drug delivery systems for targeting bacteria.
کلیدواژه‌های انگلیسی مقاله Ampicillin, Bacteria, Ferritins, Wheat germ agglutinins
نویسندگان مقاله | Qristine G. Gyurjyan
Junior researcher


| Gayane G. Poghosyan
Senior researcher


| Vardan K. Gasparyan
Head of Laboratory
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6218-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Pharmaceutical Biotechnology
نوع مقاله منتشر شده مقاله کامل
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