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Physiology and Pharmacology، جلد ۲۹، شماره ۳، صفحات ۲۷۲-۲۸۳
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عنوان انگلیسی Neuroprotective effects of Caffeic acid phenethyl ester administered with levodopa and benserazide in a rat model of Parkinson’s disease
چکیده انگلیسی مقاله Introduction: Parkinson’s disease (PD) is a neurological disorder caused by the pathological destruction of dopaminergic neurons. Although it is commonly associated with motor symptoms, most patients also experience a range of non-motor symptoms, including mental health issues such as anxiety, depression, and memory loss. In this study, we investigated the effect of caffeic acid phenethyl ester (CAPE) on improving PD and reducing the side effects of levodopa.
Methods: Forty-nine male rats were randomly divided into seven groups. A PD model was induced by unilateral injection of 6-OHDA. A combination therapy involving three doses of CAPE (10, 20, and 40 μmol/kg) was administered, along with levodopa and benserazide. The animals were assessed during the study using various behavioral tests, such as tail suspension swing, apomorphine-induced rotation, elevated plus-maze, and open f ield. Additionally, histological tests, including Nissl staining and tyrosine hydroxylase (TH) immunohistochemistry, were performed to evaluate the animals further.
Results: Our research demonstrates that CAPE effectively reduces side effects associated with levodopa. Moreover, at higher doses, CAPE significantly improves non-motor symptoms, including anxiety and depression, in addition to enhancing motor function. Histological analysis also suggests a protective effect of CAPE on dopaminergic neurons in the substantia nigra.
Conclusion: The findings of this study suggest that co-administration of CAPE can help prevent L-DOPA-induced anxiety-like behaviors through its neuroprotective properties. Therefore, CAPE may have the potential as an adjunct therapy for the management of PD.
کلیدواژه‌های انگلیسی مقاله Parkinson’s disease,Caffeic acid phenethyl ester,Motor activity,levodopa,Benserazide
نویسندگان مقاله | Zohreh Mohsenvand
Nervous System Stem Cells Research Center, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran


| Hamid Reza Sameni
Nervous System Stem Cells Research Center, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran


| Ali ghanbari
Research Center of Physiology, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran


| Majid Mirmohammadkhani
Research Center for Social Determinants of Health Community Medicine Department, Semnan University of Medical Sciences, Semnan, Iran


| abbas ali vafaei
Research Center of Physiology, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran


| Houman Parsaei
Nervous System Stem Cells Research Center, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran


| Maryam Ezzedin
Nervous System Stem Cells Research Center, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran


| Seyed Ali Seyedinia
Nervous System Stem Cells Research Center, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran


| Parnia Tarahomi
Nervous System Stem Cells Research Center, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran


| manouchehr safari
Nervous System Stem Cells Research Center, Research Institute of Neurosciences, Semnan University of Medical Sciences, Semnan, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-2484-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurophysiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
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